Potential human transmission of amyloid β pathology: surveillance and risks

被引：52

作者：

Lauwers, Elsa ^{[1
,2
]}

Lalli, Giovanna ^{[6
]}

Brandner, Sebastian ^{[7
,13
]}

Collinge, John ^{[8
]}

Compernolle, Veerle ^{[14
,15
]}

Duyckaerts, Charles ^{[16
,17
]}

Edgren, Gustaf ^{[19
,20
]}

Haik, Stephane ^{[16
,17
,18
]}

Hardy, John ^{[6
,7
,9
,21
,22
]}

Helmy, Adel ^{[23
]}

Ivinson, Adrian J. ^{[6
]}

Jaunmuktane, Zane ^{[10
,11
,13
]}

Jucker, Mathias ^{[24
,25
]}

Knight, Richard ^{[26
,27
,28
]}

Lemmens, Robin ^{[1
,2
,29
]}

Lin, I-Chun ^{[6
]}

Love, Seth ^{[32
]}

Mead, Simon ^{[8
]}

Perry, V. Hugh ^{[6
]}

Pickett, James ^{[33
,34
]}

Poppy, Guy ^{[35
]}

Radford, Sheena E. ^{[36
]}

Rousseau, Frederic ^{[1
,3
]}

Routledge, Carol ^{[37
]}

Schiavo, Giampietro ^{[6
,12
]}

Schymkowitz, Joost ^{[1
,3
]}

Selkoe, Dennis J. ^{[38
,39
]}

Smith, Colin ^{[26
]}

Thal, Dietmar R. ^{[4
,30
]}

Theys, Tom ^{[31
]}

Tiberghien, Pierre ^{[40
,41
]}

van den Burg, Peter ^{[42
,43
]}

Vandekerckhove, Philippe ^{[5
,14
]}

Walton, Clare ^{[33
,45
]}

Zaaijer, Hans L. ^{[44
]}

Zetterberg, Henrik ^{[6
,7
,46
,47
]}

De Strooper, Bart ^{[1
,2
,6
]}

机构：

[1] Katholieke Univ Leuven, VIB KU Leuven Ctr Brain & Dis Res, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Cellular & Mol Med, Leuven, Belgium

[4] Katholieke Univ Leuven, Dept Imaging & Pathol, Leuven, Belgium

[5] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium

[6] UCL, UK Dementia Res Inst, London WC1E 6BT, England

[7] UCL, Dept Neurodegenerat Dis, UCL Queen Sq Inst Neurol, London, England

[8] UCL, Med Res Council, Prion Unit, UCL,Inst Prion Dis, London, England

[9] UCL, Reta Lila Weston Inst, UCL Queen Sq Inst Neurol, London, England

[10] UCL, Dept Clin & Movement Neurosci, UCL Queen Sq Inst Neurol, London, England

[11] UCL, Queen Sq Brain Bank Neurol Disorders, Queen Sq Inst Neurol, London, England

[12] UCL, Dept Neuromuscular Disorders, UCL Queen Sq Inst Neurol, London, England

[13] Univ Coll London Natl Hlth Serv Fdn Trust, Div Neuropathol, Natl Hosp Neurol & Neurosurg, London, England

[14] Belgian Red Cross Flanders, Blood Serv, Mechelen, Belgium

[15] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium

[16] Sorbonne Univ, Inst Cerveau & Moelle Epiniere, CNRS UMR, INSERM, Paris, France

[17] Hop La Pitie Salpetriere, AP HP, Lab Neuropathol Raymond Escourolle, Paris, France

[18] Hop La Pitie Salpetriere, AP HP, Cellule Natl Reference Malad Creutzfeldt Jakob, Paris, France

[19] Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden

[20] Soder Sjukhuset, Dept Cardiol, Stockholm, Sweden

[21] Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London, England

[22] Hong Kong Univ Sci & Technol, Inst Adv Study, Hong Kong, Peoples R China

[23] Univ Cambridge, Dept Clin Neurosci, Div Neurosurg, Cambridge, England

[24] Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany

[25] Ctr Neurodegenerat Dis, Tubingen, Germany

[26] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[27] Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland

[28] Western Gen Hosp, Natl Creutzfeldt Jakob Dis Res & Surveillance Uni, Edinburgh, Midlothian, Scotland

[29] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

[30] Univ Hosp Leuven, Dept Pathol, Leuven, Belgium

[31] Univ Hosp Leuven, Dept Neurosurg, Leuven, Belgium

[32] Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, Avon, England

[33] Alzheimers Soc, London, England

[34] Epilepsy Res UK, London, England

[35] Univ Southampton, Biol Sci, Southampton, Hants, England

[36] Univ Leeds, Astbury Ctr Struct Mol Biol, Sch Mol & Cellular Biol, Leeds, W Yorkshire, England

[37] Alzheimers Res UK, Cambridge, England

[38] Brigham & Womens Hosp, Dept Neurol, Ann Romney Ctr Neurol Dis, Boston, MA USA

[39] Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA

[40] Etab Francais Sang, La Plaine St Denis, France

[41] Univ Franche Comte, Unite Mixte Rech, INSERM, Besancon, France

[42] European Blood Alliance, Brussels, Belgium

[43] Sanquin, Dept Transfus Med, Amsterdam, Netherlands

[44] Sanquin, Dept Blood Borne Infect, Amsterdam, Netherlands

[45] Multiple Sclerosis Int Federat, London, England

[46] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Gothenburg, Sweden

[47] Univ Gothenburg, Sahlgrenska Acad, Clin Neurochem Lab, Gothenburg, Sweden

来源：

LANCET NEUROLOGY | 2020年 / 19卷 / 10期

基金：

英国医学研究理事会;

关键词：

CREUTZFELDT-JAKOB-DISEASE; DURA-MATER; BLOOD-TRANSFUSION; GROWTH-HORMONE; PRION; ANGIOPATHY; PROTEIN; NEURODEGENERATION; ASSOCIATION; ALZHEIMERS;

D O I：

10.1016/S1474-4422(20)30238-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid beta after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid beta through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid beta might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid beta transmission and to clarify whether other similar proteopathic seeds, such as tau or alpha-synuclein, can also be transferred iatrogenically.

引用

页码：872 / 878

页数：7

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