Interfacial properties of morpholine-2,5-dione-based oligodepsipeptides and multiblock copolymers

被引：2
|
作者：
Machatschek, Rainhard [1 ,2 ]
Schoene, Anne-Christin [1 ,2 ]
Raschdorf, Elisa [3 ]
Ihlenburg, Ramona B. J. [1 ,2 ,3 ]
Schulz, Burkhard [1 ,2 ,3 ]
Lendlein, Andreas [1 ,2 ,3 ]
机构：
[1] Helmholtz Zentrum Geesthacht, Inst Biomat Sci, Kantstr 55, D-14513 Teltow, Germany
[2] Berlin Brandenburg Ctr Regenerat Therapies, Kantstr 55, D-14513 Teltow, Germany
[3] Univ Potsdam, Inst Chem, Karl Liebknecht Str 24-25, D-14469 Potsdam, Germany
来源：
MRS COMMUNICATIONS | 2019年 / 9卷 / 01期
关键词：
BLOCK-COPOLYMER; ENZYMATIC DEGRADATION; POLY(ESTER AMIDE)S; CONTROLLED-RELEASE; FILMS; NANOCARRIERS;
D O I：
10.1557/mrc.2019.21
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Oligodepsipeptides (ODPs) with alternating amide and ester bonds prepared by ring-opening polymerization of morpholine-2,5-dione derivatives are promising matrices for drug delivery systems and building blocks for multifunctional biomaterials. Here, we elucidate the behavior of three telechelic ODPs and one multiblock copolymer containing ODP blocks at the air-water interface. Surprisingly, whereas the oligomers and multiblock copolymers crystallize in bulk, no crystallization is observed at the air-water interface. Furthermore, polarization modulation infrared reflection absorption spectroscopy is used to elucidate hydrogen bonding and secondary structures in ODP monolayers. The results will direct the development of the next ODP-based biomaterial generation with tailored properties for highly sophisticated applications.
引用
收藏
页码：170 / 180
页数：11
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