Pathology of Endocrine Disrupters

This review reports the cut-rent state of the science relative to environmental endocrine disruption in human health. An attempt is made to present objectively the issue of pathologic effects. Emphasis is placed on male and female reproductive system development and function, the potential role of environmental endocrine disruption in the induction of breast cancer, endometriosis, testicular and prostate cancer, as well as the disruption of central nervous system-pituitary integration of hormonal and sexual behavioural activity. The interrelationship of the endocrine and immune system is also considered. Some data gaps in our understanding of the environmental endocrine disruption issue are reflected in the insuficient knowledge of the prevention and medical care of endocrine disrupter dependent diseases.