Upgrading protein synthesis for synthetic biology

被引：125

作者：

O'Donoghue, Patrick ^{[1
]}

Ling, Jiqiang ^{[1
]}

Wang, Yane-Shih ^{[1
]}

Soell, Dieter ^{[1
,2
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Chem, New Haven, CT USA

来源：

NATURE CHEMICAL BIOLOGY | 2013年 / 9卷 / 10期

基金：

美国国家科学基金会;

关键词：

TRANSFER-RNA SYNTHETASE; UNNATURAL AMINO-ACIDS; GENETIC-CODE; ESCHERICHIA-COLI; QUALITY-CONTROL; IN-VIVO; EXPANSION; MISTRANSLATION; TRANSLATION; SPECIFICITY;

D O I：

10.1038/nchembio.1339

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems will require re-engineering central components of the protein synthesis machinery on the basis of a solid mechanistic biochemical understanding of the synthetic process.

引用

页码：594 / 598

页数：5

共 29 条

[1] Natural expansion of the genetic code
Ambrogelly, Alexandre
Palioura, Sotiria
Soll, Dieter
[J]. NATURE CHEMICAL BIOLOGY, 2007, 3 (01) : 29 - 35
[2] Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification
Bezerra, Ana R.
Simoes, Joao
Lee, Wanseon
Rung, Johan
Weil, Tobias
Gut, Ivo G.
Gut, Marta
Bayes, Monica
Rizzetto, Lisa
Cavalieri, Duccio
Giovannini, Gloria
Bozza, Silvia
Romani, Luigina
Kapushesky, Misha
Moura, Gabriela R.
Santos, Manuel A. S.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (27) : 11079 - 11084
[3] Bock A, 1988, Biofactors, V1, P245
[4] UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota
Campbell, James H.
O'Donoghue, Patrick
Campbell, Alisha G.
Schwientek, Patrick
Sczyrba, Alexander
Woyke, Tanja
Soell, Dieter
Podar, Mircea
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (14) : 5540 - 5545
[5] ORIGIN OF GENETIC CODE
CRICK, FHC
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1968, 38 (03) : 367 - &
[6] Functional context, biosynthesis, and genetic encoding of pyrrolysine
Gaston, Marsha A.
Jiang, Ruisheng
Krzycki, Joseph A.
[J]. CURRENT OPINION IN MICROBIOLOGY, 2011, 14 (03) : 342 - 349
[7] Glege R., 1998, NUCLEIC ACIDS RES, V26, P5017
[8] Inefficient Delivery but Fast Peptide Bond Formation of Unnatural L-Aminoacyl-tRNAs in Translation
Ieong, Ka-Weng
Pavlov, Michael Y.
Kwiatkowski, Marek
Forster, Anthony C.
Ehrenberg, Mans
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (43) : 17955 - 17962
[9] Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement
Isaacs, Farren J.
Carr, Peter A.
Wang, Harris H.
Lajoie, Marc J.
Sterling, Bram
Kraal, Laurens
Tolonen, Andrew C.
Gianoulis, Tara A.
Goodman, Daniel B.
Reppas, Nikos B.
Emig, Christopher J.
Bang, Duhee
Hwang, Samuel J.
Jewett, Michael C.
Jacobson, Joseph M.
Church, George M.
[J]. SCIENCE, 2011, 333 (6040) : 348 - 353
[10] RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites
Johnson, David B. F.
Xu, Jianfeng
Shen, Zhouxin
Takimoto, Jeffrey K.
Schultz, Matthew D.
Schmitz, Robert J.
Xiang, Zheng
Ecker, Joseph R.
Briggs, Steven P.
Wang, Lei
[J]. NATURE CHEMICAL BIOLOGY, 2011, 7 (11) : 779 - 786

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