Immunosignaturing: a critical review

被引：42
|
作者：
Sykes, Kathryn F. [1 ]
Legutki, Joseph B. [2 ]
Stafford, Phillip [2 ]
机构：
[1] HealthTell Inc, Chandler, AZ 85226 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
来源：
TRENDS IN BIOTECHNOLOGY | 2013年 / 31卷 / 01期
关键词：
peptide microarray; immunodiagnostics; antibody profiling; biomarker discovery; health monitoring; SMALL-MOLECULE MICROARRAY; PHAGE DISPLAY; MONOCLONAL-ANTIBODY; MASS-SPECTROMETRY; IMMUNE-RESPONSE; B-CELLS; PEPTIDE; IDENTIFICATION; AFFINITY; PROTEOME;
D O I：
10.1016/j.tibtech.2012.10.012
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.
引用
收藏
页码：45 / 51
页数：7
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