Immunosignaturing: a critical review

被引：43

作者：

Sykes, Kathryn F. ^{[1
]}

Legutki, Joseph B. ^{[2
]}

Stafford, Phillip ^{[2
]}

机构：

[1] HealthTell Inc, Chandler, AZ 85226 USA

[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2013年 / 31卷 / 01期

关键词：

peptide microarray; immunodiagnostics; antibody profiling; biomarker discovery; health monitoring; SMALL-MOLECULE MICROARRAY; PHAGE DISPLAY; MONOCLONAL-ANTIBODY; MASS-SPECTROMETRY; IMMUNE-RESPONSE; B-CELLS; PEPTIDE; IDENTIFICATION; AFFINITY; PROTEOME;

D O I：

10.1016/j.tibtech.2012.10.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.

引用

页码：45 / 51

页数：7

共 65 条

[1] Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies [J].