VOLTAMMETRIC DETERMINATION OF ANTI-MALARIAL DRUG AMODIAQUINE AT A BORON-DOPED DIAMOND ELECTRODE SURFACE IN AN ANIONIC SURFACTANT MEDIA

In this study, the electrochemical determination of the amodiaquine (ADQ) drug was evaluated us-ing an electrochemically pretreated boron-doped diamond (BDD) electrode due to the enhanced surface activity. The cyclic voltammogram results of ADQ were given as single reversible and diffusion-controlled peaks at +0.48 V for the oxidation peak and +0.05 V for the reduction peak (vs. Ag/AgCl) in Britton-Robinson (BR) buffer at pH 8.0. The peak potential and current signals of ADQ were evaluated at the surface of the BDD electrode using instrumental parameters to develop a simple method for ADQ de-tection. Also, the effect of an anionic surfactant, sodium dodecyl sulfate (SDS), on the adsorption ap-plicability of the BDD electrode significantly increased the stripping voltammetric determination of ADQ. Under the optimal conditions chosen and employing square-wave adsorptive stripping voltamme-try at the BDD electrode, ADQ was determined at + 0.34 V (vs. Ag/AgCl) at the open-circuit condition in BR buffer at pH 8.0 in the presence of 2 center dot 10-4 mol l-1 SDS. Furthermore, analytical parameters showed the linear relationship for ADQ determination in the concentration range of 0.1-20.0 mu g ml-1 (2.2 center dot 10-7 - 4.3 center dot 10-5 mol l-1), with a detection limit of 0.03 mu g ml-1 (6.5 center dot 10-8 mol l-1). The proposed approach can be applied to determine ADQ in water samples.