Real-time handheld multispectral optoacoustic imaging

被引:103
作者
Buehler, Andreas [1 ]
Kacprowicz, Marcin [2 ]
Taruttis, Adrian [1 ,3 ]
Ntziachristos, Vasilis [1 ,3 ]
机构
[1] Helmholtz Zentrum Muchen, Inst Biol & Med Imaging, D-85764 Neuherberg, Germany
[2] iThera Med GmbH, D-85764 Neuherberg, Germany
[3] Tech Univ Munich, Chair Biol Imaging, D-81675 Munich, Germany
基金
欧洲研究理事会;
关键词
PHOTOACOUSTIC TOMOGRAPHY;
D O I
10.1364/OL.38.001404
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first handheld MSOT imaging device with fast wavelength tuning achieving a frame rate of 50 Hz. In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers. (C) 2013 Optical Society of America
引用
收藏
页码:1404 / 1406
页数:3
相关论文
共 22 条
  • [1] Biomedical photoacoustic imaging
    Beard, Paul
    [J]. INTERFACE FOCUS, 2011, 1 (04) : 602 - 631
  • [2] Three-dimensional optoacoustic tomography at video rate
    Buehler, A.
    Dean-Ben, X. L.
    Claussen, J.
    Ntziachristos, V.
    Razansky, D.
    [J]. OPTICS EXPRESS, 2012, 20 (20): : 22712 - 22719
  • [3] High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography
    Buehler, Andreas
    Herzog, Eva
    Ale, Angelica
    Smith, Bradley D.
    Ntziachristos, Vasilis
    Razansky, Daniel
    [J]. EJNMMI RESEARCH, 2012, 2 : 1 - 6
  • [4] Video rate optoacoustic tomography of mouse kidney perfusion
    Buehler, Andreas
    Herzog, Eva
    Razansky, Daniel
    Ntziachristos, Vasilis
    [J]. OPTICS LETTERS, 2010, 35 (14) : 2475 - 2477
  • [5] Non-invasive carotid imaging using optoacoustic tomography
    Dima, Alexander
    Ntziachristos, Vasilis
    [J]. OPTICS EXPRESS, 2012, 20 (22): : 25044 - 25057
  • [6] Dima Alexander, 2011, Expert Opin Med Diagn, V5, P263, DOI 10.1517/17530059.2011.561315
  • [7] Deep-Tissue Photoacoustic Tomography of a Genetically Encoded Near-Infrared Fluorescent Probe
    Filonov, Grigory S.
    Krumholz, Arie
    Xia, Jun
    Yao, Junjie
    Wang, Lihong V.
    Verkhusha, Vladislav V.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (06) : 1448 - 1451
  • [8] Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature
    Fronheiser, Matthew P.
    Ermilov, Sergey A.
    Brecht, Hans-Peter
    Conjusteau, Andre
    Su, Richard
    Mehta, Ketan
    Oraevsky, Alexander A.
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (02)
  • [9] A real-time photoacoustic tomography system for small animals
    Gamelin, John
    Maurudis, Anastasios
    Aguirre, Andres
    Huang, Fei
    Guo, Puyun
    Wang, Lihong V.
    Zhu, Quing
    [J]. OPTICS EXPRESS, 2009, 17 (13): : 10489 - 10498
  • [10] Optical Imaging of Cancer Heterogeneity with Multispectral Optoacoustic Tomography
    Herzog, Eva
    Taruttis, Adrian
    Beziere, Nicolas
    Lutich, Andrey A.
    Razansky, Daniel
    Ntziachristos, Vasilis
    [J]. RADIOLOGY, 2012, 263 (02) : 461 - 468