Rap1 GTPase regulation of adherens junction positioning and cell adhesion

被引：200
|
作者：
Knox, AL
Brown, NH
机构：
[1] Wellcome CRC Inst, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Anat, Cambridge CB2 1QR, England
来源：
SCIENCE | 2002年 / 295卷 / 5558期
关键词：
D O I：
10.1126/science.1067549
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cell-cell junctions are distributed evenly around the lateral circumference of cells within an epithelium. We find that the even distribution of adherens junctions is an active process that requires the small guanosine triphosphatase Rap1. Cells mutant for Rap1 condensed their adherens junctions to one side of the cell. This disrupted normal epithelial. cell behavior, and mutant cell clones dispersed into the surrounding wild-type tissue. Rap1 is enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring. The regulation of adherens junction positioning could play a role in cell mobility and cell division.
引用
收藏
页码：1285 / 1288
页数：4
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