Synthesis and Antimicrobial Activity of Carboxymethylchitin Derivatives

被引：3

作者：

Dudarev, V. G. ^{[1
]}

Tikhomirova, O. M. ^{[1
]}

Iozep, A. A. ^{[1
]}

机构：

[1] St Petersburg State Chemicopharmaceut Acad, St Petersburg 197022, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2013年 / 47卷 / 01期

关键词：

carboxymethylchitin derivatives; synthesis; antimicrobial activity;

D O I：

10.1007/s11094-013-0890-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Aminopenicillanic acid, ampicillin, amoxycillin, cephalexin, and 5-nitrofurfural were covalently attached to carboxymethylchitin using its hydrazide and azide. The resulting polymeric analogs of drugs retained antimicrobial activity, albeit on a somewhat decreased level.

引用

页码：31 / 34

页数：4

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