Sonodynamic therapy (SDT): A novel treatment of cancer based on sonosensitizer liposome as a new drug carrier

被引:25
作者
Dai, Zhi-Jun [1 ]
Li, Sha [2 ]
Gao, Jie [3 ]
Xu, Xiao-Na [2 ]
Lu, Wang-Feng [1 ]
Lin, Shuai [1 ]
Wang, Xi-Jing [1 ]
机构
[1] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Oncol, Xian 710004, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Med, Dept Pharm, Xian 710061, Peoples R China
[3] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Nephrol, Xian 710004, Peoples R China
基金
中国国家自然科学基金;
关键词
ULTRASOUND; DELIVERY; TUMOR; MECHANISMS; EXPOSURE; CELLS;
D O I
10.1016/j.mehy.2012.12.009
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cancer is a major cause of morbidity and mortality. Chemotherapy is one of the main means of cancer treatment. Conventional chemotherapy agents kill rapidly proliferating cells, resulting in some of the most common side effects of chemotherapy. Liposome-encapsulated drugs offer the possibility to increase target efficacy as well as reducing toxic side effects of chemotherapeutic drugs. However, the target specificity of liposome is dissatisfied. We urgently need to develop new approaches to improving drug target efficacy. Recently, sonodynamic therapy (SDT) of cancer, which is based on preferential uptake and retention of a sonosensitizer in tumor tissues and subsequent activation of drug by ultrasound radiation, is a developing field. In this article, we propose the use of sonosensitizers in combination with liposome to target chemotherapy drugs directly to tumor cells. SDT with low-intensity ultrasound combined with a sonosensitizer may be a promising approach to cancer therapy. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:300 / 302
页数:3
相关论文
共 38 条
[1]   Intracranial temperature elevation from diagnostic ultrasound [J].
Barnett, SB .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2001, 27 (07) :883-888
[2]  
Besic Erim, 2007, Acta Pharmaceutica (Zagreb), V57, P249, DOI 10.2478/v10007-007-0021-9
[3]   Ultrasound mediated delivery of drugs and genes to solid tumors [J].
Frenkel, Victor .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (10) :1193-1208
[4]   FCLA chemiluminescence from sonodynamic action in vitro and in vivo [J].
He, YH ;
Xing, D ;
Yan, GH ;
Ueda, K .
CANCER LETTERS, 2002, 182 (02) :141-145
[5]   The use of ultrasound and micelles in cancer treatment [J].
Husseini, Ghaleb A. ;
Pitt, William G. .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2008, 8 (05) :2205-2215
[6]  
Huwyler J, 2008, INT J NANOMED, V3, P21
[7]   Increased accumulation of paclitaxel and doxorubicin in proliferating capillary cells and prostate cancer cells following ultrasound exposure [J].
Jackson, John K. ;
Pirmoradi, Fatemeh Nazly ;
Wan, Chung-Ping Leon ;
Siu, Tung ;
Chiao, Mu ;
Burt, Helen M. .
ULTRASONICS, 2011, 51 (08) :932-939
[8]   A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems [J].
Kaminskas, Lisa M. ;
McLeod, Victoria M. ;
Kelly, Brian D. ;
Sberna, Gian ;
Boyd, Ben J. ;
Williamson, Mark ;
Owen, David J. ;
Porter, Christopher J. H. .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 8 (01) :103-111
[9]   Analysis on the current status of targeted drug delivery to tumors [J].
Kwon, Il Keun ;
Lee, Sang Cheon ;
Han, Bumsoo ;
Park, Kinam .
JOURNAL OF CONTROLLED RELEASE, 2012, 164 (02) :108-114
[10]   Application of targeted drug delivery system in Chinese medicine [J].
Li, Di-Cai ;
Zhong, Xian-Ke ;
Zeng, Zhi-Ping ;
Jiang, Jian-Guo ;
Li, Lin ;
Zhao, Mou-Ming ;
Yang, Xiao-Quan ;
Chen, Jian ;
Zhang, Ben-Shan ;
Zhao, Qiang-Zhong ;
Xie, Ming-Yong ;
Xiong, Hua ;
Deng, Ze-Yuan ;
Zhang, Xiao-Ming ;
Xu, Shi-Ying ;
Gao, Yan-Xiang .
JOURNAL OF CONTROLLED RELEASE, 2009, 138 (02) :103-112