Selective Reduction of Carboxylic Acids to Aldehydes Catalyzed by B(C6F5)3

被引：86
作者：
Bezier, David [1 ]
Park, Sehoon [1 ]
Brookhart, Maurice [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 03期
基金：
美国国家科学基金会;
关键词：
ONE-POT CONVERSION; CHEMOSELECTIVE CONVERSION; ORGANIC-COMPOUNDS; METHYL SULFIDE; HYDROGENATION; CHLORIDE; HYDRIDE; KETONES; HYDROSILATION;
D O I：
10.1021/ol303296a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
B(C6F5)(3) efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol %, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes in good to excellent yields.
引用
收藏
页码：496 / 499
页数：4
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