Human cathelicidin LL-37 prevents bacterial biofilm formation

被引:5
作者
Jacobsen, Andreas S. [1 ]
Jenssen, Havard [1 ]
机构
[1] Roskilde Univ, Dept Sci Syst & Models, Roskilde, Denmark
关键词
ANTIMICROBIAL PEPTIDE LL-37; PSEUDOMONAS-AERUGINOSA BIOFILMS; CYSTIC-FIBROSIS PATIENTS; SEVERE CONGENITAL NEUTROPENIA; HOST-DEFENSE; STAPHYLOCOCCUS-EPIDERMIDIS; EPITHELIAL-CELLS; ANTIBACTERIAL PEPTIDES; ESCHERICHIA-COLI; GENE-EXPRESSION;
D O I
10.4155/FMC.12.97
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Human pathogens often colonize their host by the formation of biofilms. These surface-attached aggregates of bacteria are characterized by a self-produced extracellular matrix, which makes them highly resistant towards antibiotic treatment. Their abilities to adhere to abiotic surfaces (e.g., catheters and other medical devices) also makes bacterial biofilm formation a challenge in modern medicine. Antimicrobial peptides have lately been introduced as a potential class of drug molecules for combating severe hospital-acquired infections. One of these peptides, human cathelicidin LL-37, has recently been demonstrated to bridge innate and adaptive host defence, in addition to facilitating a robust antibiofilm effect at sub-inhibitory concentrations. In this review we will discuss the evidence, potential and challenges for LL-37 as a candidate molecule for therapeutic use.
引用
收藏
页码:1587 / 1599
页数:13
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