Nanotechnology Responses to COVID-19

被引:117
作者
Ruiz-Hitzky, Eduardo [1 ]
Darder, Margarita [1 ]
Wicklein, Bernd [1 ]
Ruiz-Garcia, Cristina [2 ]
Martin-Sampedro, Raquel [1 ,3 ]
del Real, Gustavo [3 ]
Aranda, Pilar [1 ]
机构
[1] ICMM CSIC, Mat Sci Inst Madrid, C Sor Juana Ines de la Cruz 3, Madrid 28049, Spain
[2] Univ Orleans, CEMHTI, CNRS UPR 3079, F-45071 Orleans, France
[3] Natl Inst Agr & Food Res, INIA, Ctra la Coruna Km 7-5, Madrid 28040, Spain
关键词
coronavirus; COVID-19; diagnosis; nanomaterials; nanotechnology; treatment; vaccines; MESSENGER-RNA VACCINES; INFLUENZA-VIRUS; PHOTOCATALYTIC DISINFECTION; ANTIVIRAL PROPERTIES; LIPID NANOPARTICLES; CURRENT KNOWLEDGE; SARS CORONAVIRUS; GRAPHENE OXIDE; CARBON DOTS; INACTIVATION;
D O I
10.1002/adhm.202000979
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Researchers, engineers, and medical doctors are made aware of the severity of the COVID-19 infection and act quickly against the coronavirus SARS-CoV-2 using a large variety of tools. In this review, a panoply of nanoscience and nanotechnology approaches show how these disciplines can help the medical, technical, and scientific communities to fight the pandemic, highlighting the development of nanomaterials for detection, sanitation, therapies, and vaccines. SARS-CoV-2, which can be regarded as a functional core-shell nanoparticle (NP), can interact with diverse materials in its vicinity and remains attached for variable times while preserving its bioactivity. These studies are critical for the appropriate use of controlled disinfection systems. Other nanotechnological approaches are also decisive for the development of improved novel testing and diagnosis kits of coronavirus that are urgently required. Therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. A brief overview on patented work is presented that emphasizes nanotechnology applied to coronaviruses. Finally, some comments are made on patents of the initial technological responses to COVID-19 that have already been put in practice.
引用
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页数:26
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