Broad-complex, tramtrack, and bric-a-brac (BTB) proteins: Critical regulators of development

被引：87

作者：

Chaharbakhshi, Edwin ^{[1
,2
]}

Jemc, Jennifer C. ^{[1
]}

机构：

[1] Loyola Univ, Dept Biol, 1032 W Sheridan Rd, Chicago, IL 60626 USA

[2] Loyola Univ Chicago, Stritch Sch Med, Maywood, IL 60153 USA

来源：

GENESIS | 2016年 / 54卷 / 10期

关键词：

early development; insect; organogenesis; transcription; LEUKEMIA ZINC-FINGER; DROSOPHILA GAGA FACTOR; ACUTE PROMYELOCYTIC LEUKEMIA; POSITION-EFFECT VARIEGATION; ENHANCER-BLOCKING ACTIVITY; ZF TRANSCRIPTION FACTORS; AXON GUIDANCE GENE; POLYCOMB-GROUP; DNA-BINDING; POZ DOMAIN;

D O I：

10.1002/dvg.22964

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Broad-complex, Tramtrack, and Bric-a-brac/poxvirus and zinc finger (BTB/POZ) family proteins are a diverse family of proteins that are characterized by the presence of a common protein-protein interaction domain, known as the BTB domain. BTB proteins have been identified in poxviruses and many eukaryotes, and have diverse functions, ranging from transcriptional regulation and chromatin remodeling to protein degradation and cytoskeletal regulation. Specificity of function is determined in part by additional domains present in BTB family proteins, as well as by interaction partners. Studies of BTB proteins in Drosophila and mammalian systems have revealed the importance of these genes in multiple developmental contexts, as well as in cancer and neurological and musculoskeletal diseases. In this review, we discuss the functions of BTB/POZ proteins during development with an emphasis on BTB-zinc finger (BTB-ZF) proteins, which play critical roles in transcriptional regulation and chromatin remodeling.

引用

页码：505 / 518

页数：14

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