Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake

被引：47

作者：

Tian, Xiaozhu ^{[1
]}

Li, Rong ^{[1
]}

Jiang, Yiming ^{[2
]}

Zhao, Fei ^{[3
]}

Yu, Zhengsheng ^{[1
]}

Wang, Yiqing ^{[4
]}

Dong, Zixing ^{[5
,6
]}

Liu, Pu ^{[1
]}

Li, Xiangkai ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Minist Educ, Key Lab Cell Act & Stress Adaptat, Tianshui South Rd 222, Lanzhou 730000, Gansu, Peoples R China

[2] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Virol VIRO, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[3] Med Coll Northwest Minzu Univ, Lanzhou 730030, Gansu, Peoples R China

[4] Lanzhou Univ, Reprod Med Special Hosp, Hosp 1, Lanzhou, Gansu, Peoples R China

[5] Nanyang Normal Univ, Henan Prov Engn Lab Insect Bioreactor, Nanyang 473061, Henan, Peoples R China

[6] Nanyang Normal Univ, Henan Key Lab Ecol Secur Water Reg Midline South, Nanyang 473061, Henan, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 72卷

关键词：

Bifidobacterium breve ATCC15700; Alcoholic liver disease; Immune homeostasis; Inflammation; Intestinal barrier function; Gut microbiota; INTESTINAL PERMEABILITY; ALDEHYDE DEHYDROGENASE; MOUSE MODEL; INJURY; DYSBIOSIS; INFLAMMATION; PROTECTION; DEPENDENCE; PROBIOTICS; ENZYMES;

D O I：

10.1016/j.jff.2020.104045

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Gut microbiota has been identified as a key player in the development of alcoholic liver disease (ALD). Targeting gut microbiota with probiotic intervention will be an attractive approach to prevent ALD. Here, we investigated the effects of probiotic Bifidobacterium breve ATCC15700 (ATCC15700) on liver injury and gut microbiota in mice exposed to chronic alcohol intake. Our results showed that oral administration of ATCC15700 significantly decreased endotoxemia, maintained immune homeostasis, and alleviated alcohol-induced liver injury. ATCC15700 also promoted intestinal barrier function by enhancing the expressions of tight junction proteins in alcohol-treated mice. Moreover, analysis of gut microbiota showed that ATCC15700 normalized the structure and composition of the alcohol-disrupted gut microbiota. Correlation between gut microbiota and liver injury parameters revealed that specific bacteria, including S24_7, unclassified Clostridiales, Butyricicoccus, Oscillospira, Ruminococcus, Mucispirillum and unclassified Lachnospiraceae, were predominantly associated with ALD. In conclusion, ATCC15700 protected alcohol-exposed mice against liver injury via modulating gut micobiota.

引用

页数：12

共 46 条

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