Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis

被引：24

作者：

Sato, Takashi ^{[1
]}

Saito, Yoshiaki

Inoue, Satoshi ^{[2
]}

Shimosato, Takeshi ^{[3
]}

Takagi, Shigeto ^{[4
]}

Kaneko, Takeshi ^{[1
]}

Ishigatsubo, Yoshiaki ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Yokohama, Kanagawa 232, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Clin Res, Yokohama, Kanagawa 232, Japan

[3] Shinshu Univ, Grad Sch Agr, Minamiminowa, Japan

[4] Seamens Insurance AMHTS Clin, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2012年 / 54卷 / 12期

关键词：

C-REACTIVE PROTEIN; OBSTRUCTIVE PULMONARY-DISEASE; LONGITUDINAL DECLINE; COAL-MINERS; SMOKING CESSATION; GOLD MINERS; FEV1; POLYMORPHISMS; DUST; INFLAMMATION;

D O I：

10.1097/JOM.0b013e3182636e93

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To identify predictive factors of excess decline in forced expiratory volume in one second (FEV1) in patients with chronic silicosis. Methods: Forty-six male patients enrolled in 2004 were screened and received pulmonary function tests. Results: Among the 33 included patients, 12 were categorized as rapid decliners (reduction in FEV1 > 60 mL/yr). The mean level of serum heme oxygenase-1 (HO-1), a marker of oxidative stress, was significantly lower in rapid decliners than in normal decliners (P = 0.002). Logistic regression analysis revealed that serum HO-1 was a factor affecting clinically important decline in FEV1 (odds ratio = 0.52; 95% confidence interval, 0.31 to 0.88) independent of the effects of age, height, weight, smoking, exposure status, and C-reactive protein. Conclusions: Serum HO-1 may be a predictor of lung function decline in silicosis patients.

引用

页码：1461 / 1466

页数：6

共 39 条

[1]

[Anonymous], AM J RESP CRIT CARE

[2] Silicosis: Expiratory thin-section CT assessment of airway obstruction [J].