Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

被引:20
|
作者
Wang, Jun-mei [1 ]
Qu, Ze-qiang [1 ]
Wu, Jin-lang [2 ]
Chung, Peter [3 ]
Zeng, Yuan-shan [1 ,4 ,5 ,6 ]
机构
[1] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Histol & Embryol, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Electron Microscope, Guangzhou, Guangdong, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Shanghai, Peoples R China
[4] Sun Yat Sen Univ, Inst Spinal Cord Injury, Guangzhou, Guangdong, Peoples R China
[5] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China
[6] Sun Yat Sen Univ, Zhongshan Sch Med, Guangdong Prov Key Lab Brain Funct & Dis, Guangzhou, Guangdong, Peoples R China
关键词
nerve regeneration; Alzheimer's disease; intracerebroventricular injection; streptozotocin; neuronal apoptosis; neuroprotection; cytochrome c oxidase; adenosine triphosphate; caspase-3; NeuN; neural regeneration; GROWTH-FACTOR-I; SPATIAL MEMORY IMPAIRMENT; LOW-DOSE REGIMEN; INTRACEREBROVENTRICULAR STREPTOZOTOCIN; OXIDATIVE STRESS; INSULIN-RECEPTOR; GLUCOSE-METABOLISM; DIABETES-MELLITUS; ENERGY-METABOLISM; FRONTAL-CORTEX;
D O I
10.4103/1673-5374.221160
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata (RCE) improved spatial cognition in a rat model of Alzheimer's disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer's disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer's disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer's disease.
引用
收藏
页码:2025 / 2034
页数:10
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