A novel report of clg-FISH and cytogenetics in POEMS syndrome

被引：13

作者：

Bryce, Alan H.

Ketterling, Rhett P. ^{[1
]}

Gertz, Morie A.

Lacy, Martha

Knudson, Ryan A. ^{[1
]}

Kumar, Shaji ^{[1
]}

Kyle, Robert A. ^{[1
]}

Fonseca, Rafael ^{[2
]}

Greipp, Phillip R. ^{[1
]}

Lust, John A. ^{[1
]}

Rajkumar, Vincent S. ^{[1
]}

Hayman, Suzanne R.

Buadi, Francis

Russell, Stephen J.

Zeldenrust, Stephen R.

Dispenzieri, Angela ^{[1
]}

机构：

[1] Mayo Clin, Lab Med & Pathol, Rochester, MN USA

[2] Mayo Clin, Scottsdale, AZ USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2008年 / 83卷 / 11期

关键词：

D O I：

10.1002/ajh.21285

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (clg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which clg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) clg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique. Am. J. Hematol. 83:840-841, 2008. (C) 2008 Wiley-Liss, Inc.

引用

页码：840 / 841

页数：2

共 12 条

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