Safety Assessment of Talc as Used in Cosmetics

被引：38

作者：

Fiume, Monice M. ^{[1
]}

Boyer, Ivan ^{[1
]}

Bergfeld, Wilma F. ^{[1
]}

Belsito, Donald V. ^{[1
]}

Hill, Ronald A. ^{[1
]}

Klaassen, Curtis D. ^{[1
]}

Liebler, Daniel C. ^{[1
]}

Marks, James G., Jr. ^{[1
]}

Shank, Ronald C. ^{[1
]}

Slaga, Thomas J. ^{[1
]}

Snyder, Paul W. ^{[1
]}

Andersen, F. Alan ^{[1
]}

机构：

[1] Cosmet Ingredient Rev, Washington, DC USA

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2015年 / 34卷

关键词：

talc; safety; cosmetics; EPITHELIAL OVARIAN-CANCER; PERINEAL POWDER EXPOSURE; NEUTRON-ACTIVATED TALC; RISK-FACTORS; LUNG-CANCER; RETROGRADE MIGRATION; PULMONARY TALCOSIS; RESPIRATORY HEALTH; MESOTHELIAL CELLS; GLOVE POWDER;

D O I：

10.1177/1091581815586797

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of talc for use in cosmetics. The safety of talc has been the subject of much debate through the years, partly because the relationship between talc and asbestos is commonly misunderstood. Industry specifications state that cosmetic-grade talc must contain no detectable fibrous, asbestos minerals. Therefore, the large amount of available animal and clinical data the Panel relied on in assessing the safety of talc only included those studies on talc that did not contain asbestos. The Panel concluded that talc is safe for use in cosmetics in the present practices of use and concentration (some cosmetic products are entirely composed of talc). Talc should not be applied to the skin when the epidermal barrier is missing or significantly disrupted.

引用

页码：66S / 129S

页数：64

共 214 条

[21]

[Anonymous], 1994, IND MINERALS ROCKS S

[22]

[Anonymous], REQUEST QUANTI UNPUB

[23]

[Anonymous], FED REG

[24]

[Anonymous], NIH PUBL

[25]

[Anonymous], CTFA COMP COSM INGR

[26]

[Anonymous], SAMPLE CERTIFICATE A

[27]

[Anonymous], 600891217 EPA OFF RE

[28]

[Anonymous], COMMENTS TOXICOL

[29]

[Anonymous], HLTH EFFECTS PHYLLOS

[30]

[Anonymous], PRIOR NDA BLA APPR 2

← 1 2 3 4 5 6 7 8 9 10 →