Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents

被引:35
作者
Tahlan, Sumit [1 ]
Kumar, Sanjiv [1 ]
Ramasamy, Kalavathy [2 ,3 ]
Lim, Siong Meng [2 ,3 ]
Shah, Syed Adnan Ali [2 ,4 ]
Mani, Vasudevan [5 ]
Pathania, Ranjana [6 ]
Narasimhan, Balasubramanian [1 ]
机构
[1] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India
[2] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
[3] Univ Teknol MARA UiTM, Collaborat Drug Discovery Res CDDR Grp, Pharmaceut Life Sci Community Res, Shah Alam 40450, Selangor, Malaysia
[4] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia
[5] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia
[6] Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India
关键词
Antibacterial; Antifungal; Anticancer; 2-Mercaptobenzimidazole; SAR; DERIVATIVES; BASES;
D O I
10.1186/s13065-019-0567-x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Background: Nitrogen containing heterocycles are widely used and investigated by pharmaceutical industry, as they are important in discovery and designing of new drug molecules. Drugs with a benzimidazole nucleus possess exclusive structural features and electron-rich atmosphere, which enable them to bind to a number of biologically important targets and result in a wide range of activities. This has served as the basis of the present study whereby new scaffolds with benzimidazole moiety were designed and synthesized. Methods: The structures of synthesized compounds were confirmed by physicochemical and spectral means. The synthesized compounds were screened for their antimicrobial and antiproliferative activities by tube dilution and Sulforhodamine B (SRB) assays, respectively. Results and conclusion: The in vitro biological screening results revealed that compound Z24 exhibited promising antimicrobial and anticancer activities which are comparable to standards.
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页数:15
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