Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs

被引：14

作者：

Li, Jing ^{[1
,2
]}

Zhong, Xianmei ^{[3
,4
,5
,6
]}

Zhao, Yueshui ^{[3
,4
,5
]}

Shen, Jing ^{[3
,4
,5
]}

Pilapong, Chalermchai ^{[2
,7
]}

Xiao, Zhangang ^{[3
,4
,5
]}

机构：

[1] Southwest Med Univ, Dept Oncol & Hematol, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Peoples R China

[2] Chiang Mai Univ, Fac Associated Med Sci, Ctr Excellence Mol Imaging CEMI, Dept Radiol Technol, Chiang Mai 50200, Thailand

[3] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Peoples R China

[4] Southwest Med Univ, Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou 646000, Peoples R China

[5] South Sichuan Inst Translat Med, Luzhou 646000, Peoples R China

[6] Peoples Hosp Nanbu Cty, Dept Pharm, Nanchong 637300, Peoples R China

[7] Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand

来源：

MOLECULES | 2022年 / 27卷 / 18期

关键词：

polyphenol; lung cancer; microRNA; CURCUMIN PROMOTES APOPTOSIS; TOTAL PHENOLIC CONTENTS; UP-REGULATION; CELL-PROLIFERATION; K-RAS; ANTIOXIDANT CAPACITIES; INHIBITS MIGRATION; DOWN-REGULATION; A549; CELLS; PHASE-I;

D O I：

10.3390/molecules27185903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer is the second leading cause of cancer-related death worldwide. In recent decades, investigators have found that microRNAs, a group of non-coding RNAs, are abnormally expressed in lung cancer, and play important roles in the initiation and progression of lung cancer. These microRNAs have been used as biomarkers and potential therapeutic targets of lung cancer. Polyphenols are natural and bioactive chemicals that are synthesized by plants, and have promising anticancer effects against several kinds of cancer, including lung cancer. Recent studies identified that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer. In this review, we reviewed the effects of polyphenols on oncogenic and tumor-suppressive microRNAs in lung cancer. We also reviewed and discussed the potential clinical application of polyphenol-regulated microRNAs in lung cancer treatment.

引用

页数：17

共 126 条

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