Validation of Powder X-Ray Diffraction Following EN ISO/IEC 17025

被引:3
作者
Eckardt, Regina [1 ]
Krupicka, Erik [2 ]
Hofmeister, Wolfgang [1 ]
机构
[1] Johannes Gutenberg Univ Mainz, Inst Geosci, D-55099 Mainz, Germany
[2] BKA, Forens Sci Inst, D-65173 Wiesbaden, Germany
关键词
forensic science; powder X-ray diffraction; validation; EN ISO; IEC; 17025; laboratory proficiency test; trueness; specificity; selectivity; robustness; preparation errors; detection limit;
D O I
10.1111/j.1556-4029.2011.02025.x
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Powder X-ray diffraction (PXRD) is used widely in forensic science laboratories with the main focus of qualitative phase identification. Little is found in literature referring to the topic of validation of PXRD in the field of forensic sciences. According to EN ISO/IEC 17025, the method has to be tested for several parameters. Trueness, specificity, and selectivity of PXRD were tested using certified reference materials or a combination thereof. All three tested parameters showed the secure performance of the method. Sample preparation errors were simulated to evaluate the robustness of the method. These errors were either easily detected by the operator or nonsignificant for phase identification. In case of the detection limit, a statistical evaluation of the signal-to-noise ratio showed that a peak criterion of three sigma is inadequate and recommendations for a more realistic peak criterion are given. Finally, the results of an international proficiency test showed the secure performance of PXRD.
引用
收藏
页码:722 / 737
页数:16
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