MicroRNAs as a novel cellular senescence regulator

被引：40
作者：
Liu, Feng-Jiao [2 ]
Wen, Tie [1 ]
Liu, Ling [2 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Surg Emergency, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2012年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cellular senescence; MicroRNAs; Senescence-related signaling pathways; INDUCED PREMATURE SENESCENCE; SUPPRESSES TUMOR-GROWTH; REPLICATIVE SENESCENCE; NITRIC-OXIDE; OXIDATIVE STRESS; PROSTATE-CANCER; GENE-EXPRESSION; DOWN-REGULATION; UP-REGULATION; SELF-RENEWAL;
D O I：
10.1016/j.arr.2011.06.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular senescence is a program activated in normal cells in response to various types of stresses and is manifested by permanent arrest of cell cycle. Cellular senescence is closely related to tumor suppression, and may contribute to the ageing of organisms. The complex senescence cell phenotype has many different mechanisms. Recent studies have provided important insights regarding the role played by miRNAs during cellular senescence as a novel molecular mechanism. In this article, we will review the latest advances in the identification and validation of senescence-regulatory miRNAs and the possible mechanisms. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：41 / 50
页数：10
相关论文
共 50 条
  • [31] Cellular senescence: a hitchhiker's guide
    Aravinthan, Aloysious
    HUMAN CELL, 2015, 28 (02): : 51 - 64
  • [32] Foxp3 is a key downstream regulator of p53-mediated cellular senescence
    Kim, J-E
    Shin, J-S
    Moon, J-H
    Hong, S-W
    Jung, D-J
    Kim, J. H.
    Hwang, I-Y
    Shin, Y. J.
    Gong, E-Y
    Lee, D. H.
    Kim, S-M
    Lee, E. Y.
    Kim, Y. S.
    Kim, D.
    Hur, D.
    Kim, T. W.
    Kim, K-p
    Jin, D-H
    Lee, W-J
    ONCOGENE, 2017, 36 (02) : 219 - 230
  • [33] Caveolin-1, cellular senescence and age-related diseases
    Zou, Huafei
    Stoppani, Elena
    Volonte, Daniela
    Galbiati, Ferruccio
    MECHANISMS OF AGEING AND DEVELOPMENT, 2011, 132 (11-12) : 533 - 542
  • [34] MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells
    Potter, Matthew L.
    Hill, William D.
    Isales, Carlos M.
    Hamrick, Mark W.
    Fulzele, Sadanand
    BONE, 2021, 142
  • [35] Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
    Bernadotte, Alexandra
    Mikhelson, Victor M.
    Spivak, Irina M.
    AGING-US, 2016, 8 (01): : 3 - 11
  • [36] Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
    Kumari, Ruchi
    Jat, Parmjit
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 09
  • [37] Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
    Wang, Wen-Juan
    Cai, Guang-Yan
    Chen, Xiang-Mei
    ONCOTARGET, 2017, 8 (38) : 64520 - 64533
  • [38] MicroRNAs as Factors in Bidirectional Crosstalk Between Mitochondria and the Nucleus During Cellular Senescence
    Giordani, Chiara
    Silvestrini, Andrea
    Giuliani, Angelica
    Olivieri, Fabiola
    Rippo, Maria Rita
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [39] α-Fucosidase as a novel convenient biomarker for cellular senescence
    Hildebrand, Dominic G.
    Lehle, Simon
    Borst, Andreas
    Haferkamp, Sebastian
    Essmann, Frank
    Schulze-Osthoff, Klaus
    CELL CYCLE, 2013, 12 (12) : 1922 - 1927
  • [40] Cellular Senescence and Vascular Disease: Novel Routes to Better Understanding and Therapy
    Yin, Hao
    Pickering, J. Geoffrey
    CANADIAN JOURNAL OF CARDIOLOGY, 2016, 32 (05) : 612 - 623
12345