MicroRNAs as a novel cellular senescence regulator

被引：40
作者：
Liu, Feng-Jiao [2 ]
Wen, Tie [1 ]
Liu, Ling [2 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Surg Emergency, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2012年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cellular senescence; MicroRNAs; Senescence-related signaling pathways; INDUCED PREMATURE SENESCENCE; SUPPRESSES TUMOR-GROWTH; REPLICATIVE SENESCENCE; NITRIC-OXIDE; OXIDATIVE STRESS; PROSTATE-CANCER; GENE-EXPRESSION; DOWN-REGULATION; UP-REGULATION; SELF-RENEWAL;
D O I：
10.1016/j.arr.2011.06.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular senescence is a program activated in normal cells in response to various types of stresses and is manifested by permanent arrest of cell cycle. Cellular senescence is closely related to tumor suppression, and may contribute to the ageing of organisms. The complex senescence cell phenotype has many different mechanisms. Recent studies have provided important insights regarding the role played by miRNAs during cellular senescence as a novel molecular mechanism. In this article, we will review the latest advances in the identification and validation of senescence-regulatory miRNAs and the possible mechanisms. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：41 / 50
页数：10
相关论文
共 133 条
[1]   miR-519 suppresses tumor growth by reducing HuR levels [J].
Abdelmohsen, Kotb ;
Kim, Mihee M. ;
Srikantan, Subramanya ;
Mercken, Evi M. ;
Brennan, Sarah E. ;
Wilson, Gerald M. ;
de Cabo, Rafael ;
Gorospe, Myriam .
CELL CYCLE, 2010, 9 (07) :1354-1359
[2]   miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels [J].
Abdelmohsen, Kotb ;
Srikantan, Subramanya ;
Kuwano, Yuki ;
Gorospe, Myriam .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20297-20302
[3]   Complex transcriptional regulatory mechanisms control expression of the E2F3 locus [J].
Adams, MR ;
Sears, R ;
Nuckolls, F ;
Leone, G ;
Nevins, JR .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (10) :3633-3639
[4]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[5]   The signals and pathways activating cellular senescence [J].
Ben-Porath, I ;
Weinberg, RA .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (05) :961-976
[6]   A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases [J].
Benetti, Roberta ;
Gonzalo, Susana ;
Jaco, Isabel ;
Munoz, Purificacion ;
Gonzalez, Susana ;
Schoeftner, Stefan ;
Murchison, Elizabeth ;
Andl, Thomas ;
Chen, Taiping ;
Klatt, Peter ;
Li, En ;
Serrano, Manuel ;
Millar, Sarah ;
Hannon, Gregory ;
Blasco, Maria A. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (03) :268-279
[7]   Identification of hundreds of conserved and nonconserved human microRNAs [J].
Bentwich, I ;
Avniel, A ;
Karov, Y ;
Aharonov, R ;
Gilad, S ;
Barad, O ;
Barzilai, A ;
Einat, P ;
Einav, U ;
Meiri, E ;
Sharon, E ;
Spector, Y ;
Bentwich, Z .
NATURE GENETICS, 2005, 37 (07) :766-770
[8]   MicroRNAs miR-146a/b negatively modulate the senescence associated inflammatory mediators IL-6 and IL-8 [J].
Bhaumik, Dipa ;
Scott, Gary K. ;
Schokrpur, Shiruyeh ;
Patil, Christopher K. ;
Orjalo, Arturo V. ;
Rodier, Francis ;
Lithgow, Gordon J. ;
Campisi, Judith .
AGING-US, 2009, 1 (04) :402-411
[9]   Defining the molecular basis of Arf and Hdm2 interactions [J].
Bothner, B ;
Lewis, WS ;
DiGiammarino, EL ;
Weber, JD ;
Bothner, SJ ;
Kriwacki, RW .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 314 (02) :263-277
[10]   Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway [J].
Bulavin, DV ;
Phillips, C ;
Nannenga, B ;
Timofeev, O ;
Donehower, LA ;
Anderson, CW ;
Appella, E ;
Fornace, AJ .
NATURE GENETICS, 2004, 36 (04) :343-350
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