3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures

被引：5
|
作者：
Hong, Sungmin [1 ]
Sycks, Dalton [1 ]
Chan, Hon Fai [2 ]
Lin, Shaoting [1 ,3 ]
Lopez, Gabriel P. [1 ,2 ]
Guilak, Farshid [1 ,2 ,4 ]
Leong, Kam W. [2 ,5 ]
Zhao, Xuanhe [1 ,3 ,6 ]
机构：
[1] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA
[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[4] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA
[5] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
[6] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 27期
基金：
美国国家科学基金会;
关键词：
3D printing; cellularized structure; tough hydrogel; poly (ethylene glycol)-alginate; nanoclay; FRACTURE-TOUGHNESS; NETWORK HYDROGELS; CROSS-LINKING; SCAFFOLDS; CARTILAGE; STRENGTH; TISSUES; DESIGN;
D O I：
10.1002/adma.201501099
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4035 / 4040
页数：6
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