The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant

被引：9

作者：

Arora, Prerna ^{[1
,2
]}

Zhang, Lu ^{[1
,2
]}

Rocha, Cheila ^{[1
,2
]}

Graichen, Luise ^{[1
,2
]}

Nehlmeier, Inga ^{[1
]}

Kempf, Amy ^{[1
,2
]}

Cossmann, Anne ^{[3
]}

Ramos, Gema Morillas ^{[3
,4
]}

Baier, Eva ^{[5
]}

Tampe, Bjoern ^{[5
]}

Moerer, Onnen ^{[6
]}

Dickel, Steffen ^{[6
]}

Winkler, Martin S. ^{[6
]}

Behrens, Georg M. N. ^{[3
,4
,7
]}

Poehlmann, Stefan ^{[1
,2
]}

Hoffmann, Markus ^{[1
,2
]}

机构：

[1] German Primate Ctr, Infect Biol Unit, Leibniz Inst Primate Res, Kellnerweg 4, D-37077 Gottingen, Germany

[2] Georg August Univ Gottingen, Fac Biol & Psychol, Withelmspl 1, D-37073 Gottingen, Germany

[3] Hannover Med Sch, Dept Rheumatol & Immunol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[4] German Ctr Infect Res DZIF, Partner Site Hannover Braunschweig, Carl Neuberg Str 1, D-30625 Hannover, Germany

[5] Georg August Univ Gottingen, Univ Med Ctr Gottingen, Dept Nephrol & Rheumatol, Robert Koch Str 40, D-37075 Gottingen, Germany

[6] Georg August Univ Gottingen, Univ Med Ctr Gottingen, Dept Anesthesiol, Robert Koch Str 40, D-37075 Gottingen, Germany

[7] Ctr Individualised Infect Med CiiM, Feodor Lynen Str 7, D-30625 Hannover, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 22期

关键词：

SARS-CoV-2; delta variant; omicron variant; delta-omicron; deltacron; recombinant; spike protein; BA; 1; antibody evasion; neutralization; CELL ENTRY; SPIKE;

D O I：

10.3390/ijms232214057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant. This finding raised concerns that the recombinant virus might exhibit altered biological properties as compared to the parental viruses and might pose an elevated threat to human health. Here, using pseudotyped particles, we show that ACE2 binding and cell tropism of XD mimics that of BA.1. Further, XD and BA.1 displayed comparable sensitivity to neutralization by antibodies induced upon vaccination with BNT162b2/Comirnaty (BNT) or BNT vaccination followed by breakthrough infection. Our findings reveal important biological commonalities between XD and Omicron BA.1 host cell entry and its inhibition by antibodies.

引用

页数：13