The role of ovarian steroid hormones in mood

被引:27
|
作者
Schwartz, Deborah H. [1 ]
Romans, Sarah E. [2 ,5 ]
Meiyappan, Soumia [2 ]
De Souza, Mary Jane [3 ]
Einstein, Gillian [1 ,2 ,4 ]
机构
[1] Univ Toronto, Dept Psychol, Toronto, ON M5S 3G3, Canada
[2] Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON M5S 1B2, Canada
[3] Univ Toronto, Fac Phys Educ & Hlth, Toronto, ON M5S 3G3, Canada
[4] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 3G3, Canada
[5] Univ Otago Wellington, Dept Psychol Med, Wellington, New Zealand
关键词
Mood; Menstrual cycle; Estrogens; Progestagens; E1G; PdG; Stress; Social support; Physical health; MENSTRUAL-CYCLE; PREMENSTRUAL-SYNDROME; SOCIAL SUPPORT; STRESS; WOMEN; REPLACEMENT; RELIABILITY; METABOLITES; POPULATION; PREVALENCE;
D O I
10.1016/j.yhbeh.2012.08.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Fluctuations in ovarian hormones across the menstrual cycle have long been considered a determinant of mood in women. The majority of studies, however, use menstrual cycle phase as proxy for hormone levels. We measured ovarian hormone levels directly in order to examine the relationship between daily hormone levels and mood in non-help-seeking women. Participants (n = 19) provided daily information about their positive and negative moods, and collected their first morning-voided urine for 42 days, which was analyzed for estrogen and progesterone metabolites (E1G and PdG). The independent contributions of daily E1G, PdG, stress, physical health, and weekly social support, were calculated for 12 daily mood items, and composite measures of positive and negative mood items, using linear mixed models. E1G or PdG contributed to few mood items: E1G measured 2 days prior contributed negatively to the model for Motivation, while El G measured 3 days prior contributed negatively to Getting Along with Others, and El G measured 4 days prior contributed negatively to Anxiety. PdG, measured the same day and 1 day prior, contributed positively to the models of Irritability, and PdG measured 5 days prior contributed positively to Difficulty Coping. By contrast, the variables stress and physical health contributed significantly to all the mood items, as well as both composite positive and negative mood measures. These findings demonstrate that, compared to stress and physical health, ovarian hormones make only a small contribution to daily mood. Thus, fluctuations in ovarian hormones do not contribute significantly to daily mood in healthy women. (C) 2012 Elsevier Inc. All rights reserved.
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页码:448 / 454
页数:7
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