Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: A pilot study

被引：114
作者：
Tanaka, K
Ikeda, M
Nozaki, A
Kato, N
Tsuda, H
Saito, S
Sekihara, H
机构：
[1] Yokohama City Univ, Sch Med, Dept Internal Med 3, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Natl Canc Ctr, Res Inst, Expt Pathol & Chemotherapy Div, Tokyo 1040045, Japan
[3] Natl Canc Ctr, Res Inst, Div Virol, Tokyo 1040045, Japan
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1999年 / 90卷 / 04期
基金：
芬兰科学院;
关键词：
lactoferrin; chronic hepatitis; hepatitis C virus;
D O I：
10.1111/j.1349-7006.1999.tb00756.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin. a milk protein belonging to the iron transporter family, effectively prevented HCV infection in cultured human hepatocytes (PH5CH8), We tested the hypothesis that lactoferrin inhibits HCV viremia in patients with chronic hepatitis C, Eleven patients with chronic hepatitis C received an 8-week course of bovine lactoferrin (1.8 or 3.6 g/day), At the end of lactoferrin treatment, a decrease in serum alanine transaminase and HCV RNA concentrations was apparent in 3 (75%) of 4 patients with low pretreatment serum concentrations of HCV RNA. Ho However, 7 patients with high pretreatment concentrations showed no significant changes in these indices. This pilot study suggests that lactoferrin is one potential candidate as an anti-HCV reagent that mag be effective for the treatment of patients with chronic hepatitis.
引用
收藏
页码：367 / 371
页数：5
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