Association between autoimmune pancreatitis and systemic autoimmune diseases

被引:9
|
作者
Terzin, Viktoria [1 ]
Foeldesi, Imre [1 ]
Kovacs, Laszlo [2 ]
Pokorny, Gyula [2 ]
Wittmann, Tibor [1 ]
Czako, Laszlo [1 ]
机构
[1] Univ Szeged, Dept Med 1, H-6701 Szeged, Hungary
[2] Univ Szeged, Dept Rheumatol, H-6701 Szeged, Hungary
关键词
Autoimmune pancreatitis; Serum immunoglobulin G4 level; Systemic lupus erythematosus; Sjogren's syndrome; Mikulicz's disease; EXTRAPANCREATIC LESIONS; CLASSIFICATION CRITERIA; MIKULICZS-DISEASE; IGG4; AUTOANTIBODIES; FEATURES;
D O I
10.3748/wjg.v18.i21.2649
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the association between autoimmune pancreatitis (AIP) and systemic autoimmune diseases (SAIDs) by measurement of serum immunoglobulin G4 (IgG4). METHODS: The serum level of IgG4 was measured in 61 patients with SAIDs of different types who had not yet participated in glucocorticosteroid treatment. Patients with an elevated IgG4 level were examined by abdominal ultrasonography (US) and, in some cases, by computer tomography (CT). RESULTS: Elevated serum IgG4 levels (919 +/- 996 mg/L) were detected in 1.7 (28%) of the 61 SAID patients. 10 patients had Sjogren's syndrome (SS) (IgG4: 590 +/- 232 mg/L), 2 of them in association with Hashimoto's thyroiditis, and 7 patients (IgG4: 1388 +/- 985.5 mg/L) had systemic lupus erythematosus (SLE). The IgG4 level in the SLE patients and that in patients with SS were not significantly different from that in AIP patients (783 +/- 522 mg/L). Abdominal US and CT did not reveal any characteristic features of AIP among the SAID patients with an elevated IgG4 level. CONCLUSION: The serum IgG4 level may be elevated in SAIDs without the presence of AIP The determination of serum IgG4 does not seem to be suitable for the differentiation between IgG4-related diseases and SAIDs. (C) 2012 Baishideng. All rights reserved.
引用
收藏
页码:2649 / 2653
页数:5
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