Anti-chromatin (anti-nucleosome) antibodies: Diagnostic and clinical value

被引:61
|
作者
Gomez-Puerta, Jose A. [1 ]
Burlingame, Rufus W. [2 ]
Cervera, Ricard [1 ]
机构
[1] Hosp Clin Barcelona, Dept Autoimmune Dis, Barcelona 08036, Catalonia, Spain
[2] INOVA Diagnost Inc, San Diego, CA 92131 USA
关键词
Anti-chromatin antibodies; Anti-nucleosome antibodies; Systemic lupus erythematosus;
D O I
10.1016/j.autrev.2008.06.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anti-chromatin (nucleosome) autoantibodies were one of the first autoantibodies ever detected since they make up the majority of antibodies causing LE Cell formation. The prevalence of anti-chromatin antibodies in systemic lupus erythematosus (SLE) varies from 50% to 100%, being similar to that of the classical positive LE cell. The presence of these antibodies can be used, in conjunction with clinical findings and other laboratory tests, to help in the diagnosis of SLE and drug-induced lupus. Anti-chromatin antibodies have also been found in a lesser percentage of other autoimmune disorders such as primary Sjogren's syndrome and primary antiphospholipid syndrome. The presence of anti-chromatin antibodies has also been linked to glomerulonephritis and disease activity in SLE patients. Recent studies demonstrated the induction of anti-chromatin (anti-nucleosome) antibodies after an anti-tumour necrosis factor (TNF)-alpha agent treatment. (C) 2008 Elsevier B.V. All rights reserved
引用
收藏
页码:606 / 611
页数:6
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