Engineering of pharmaceutical materials: An industrial perspective

被引：118
作者：
Chow, Kwok [1 ]
Tong, Henry H. Y. [2 ]
Lum, Susan [1 ]
Chow, Albert H. L. [3 ]
机构：
[1] Patheon Inc, Pharmaceut Dev Serv, Mississauga, ON L5N 7K9, Canada
[2] Macao Polytech Inst, Sch Hlth Sci, Macau, Peoples R China
[3] Chinese Univ Hong Kong, Sch Pharm, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 97卷 / 08期
关键词：
crystal engineering; crystallization; polymorphism; selection of salt forms; particle size; preformulation; pharmaceutical manufacturing; formulation;
D O I：
10.1002/jps.21212
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes. (C) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.
引用
收藏
页码：2855 / 2877
页数：23
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