Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier

被引：54

作者：

Andras, Ibolya E. ^{[1
]}

Toborek, Michal ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Biochem & Mol Biol, Miami, FL 33136 USA

来源：

IUBMB LIFE | 2013年 / 65卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HIV-1; HIV-1-associated neurocognitive disorders; blood-brain barrier; brain endothelial cell; amyloid beta; GLYCATION END-PRODUCTS; RECEPTOR-RELATED PROTEIN-1; TAT-INDUCED ALTERATIONS; ALZHEIMERS-DISEASE; P-GLYCOPROTEIN; AIDS PATIENTS; LDL RECEPTOR; LIPID RAFTS; HIV-1; EXPRESSION;

D O I：

10.1002/iub.1106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, we face an increase in the aging of the HIV-1-infected population, which is not only due to effective antiretroviral therapy but also to new infections among older people. Even with the use of the antiretroviral therapy, HIV-associated neurocognitive disorders represent an increasing problem as the HIV-1-infected population ages. Increased amyloid beta (A beta) deposition is characteristic of HIV-1-infected brains, and it has been hypothesized that brain vascular dysfunction contributes to this phenomenon, with a critical role suggested for the blood-brain barrier in brain A beta homeostasis. This review will describe the mechanisms by which the blood-brain barrier may contribute to brain A beta accumulation, and our findings in the context of HIV-1 infection will be discussed. (c) 2012 IUBMB Life, 65(1):4349, 2013

引用

页码：43 / 49

页数：7

共 62 条

[1] Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients [J].

Achim, Cristian L. ;

Adame, Anthony ;

Dumaop, Wilmar ;

Everall, Ian P. ;

Masliah, Eliezer .

JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2009, 4 (02) :190-199

[2] HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures [J].

Aksenov, M. Y. ;

Aksenova, M. V. ;

Mactutus, C. F. ;

Booze, R. M. .

NEUROSCIENCE LETTERS, 2010, 475 (03) :174-178

[3] Simvastatin protects against amyloid β and HIV-1 tat-induced promoter activities of inflammatory genes in brain endothelial cells [J].

Andras, Ibolya E. ;

Rha, GeunBae ;

Huang, Wen ;

Eum, SungYong ;

Couraud, Pierre-Olivier ;

Romero, Ignacio A. ;

Hennig, Bernhard ;

Toborek, Michal .

MOLECULAR PHARMACOLOGY, 2008, 73 (05) :1424-1433

[4] Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells [J].

Andras, Ibolya E. ;

Eum, Sung Yong ;

Toborek, Michal .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 421 (02) :177-183

[5] HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin [J].

Andras, Ibolya E. ;

Eum, Sung Yong ;

Huang, Wen ;

Zhong, Yu ;

Hennig, Bernhard ;

Toborek, Michal .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 43 (02) :232-243

[6] Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells [J].

András, IE ;

Pu, H ;

Tian, J ;

Deli, MA ;

Nath, A ;

Hennig, B ;

Toborek, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (09) :1159-1170

[7] Clusterin mRNA and Protein in Alzheimer's Disease [J].

Baig, Shabnam ;

Palmer, Laura E. ;

Owen, Michael J. ;

Williams, Julie ;

Kehoe, Patrick G. ;

Love, Seth .

JOURNAL OF ALZHEIMERS DISEASE, 2012, 28 (02) :337-344

[8] SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells [J].

Bell, Robert D. ;

Deane, Rashid ;

Chow, Nienwen ;

Long, Xiaochun ;

Sagare, Abhay ;

Singh, Itender ;

Streb, Jeffrey W. ;

Guo, Huang ;

Rubio, Anna ;

Van Nostrand, William ;

Miano, Joseph M. ;

Zlokovic, Berislav V. .

NATURE CELL BIOLOGY, 2009, 11 (02) :143-U83

[9] RAGE (Yin) versus LRP (Yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood-brain barrier [J].

Deane, R ;

Wu, ZH ;

Zlokovic, BV .

STROKE, 2004, 35 (11) :2628-2631

[10] RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain [J].

Deane, R ;

Yan, SD ;

Submamaryan, RK ;

LaRue, B ;

Jovanovic, S ;

Hogg, E ;

Welch, D ;

Manness, L ;

Lin, C ;

Yu, J ;

Zhu, H ;

Ghiso, J ;

Frangione, B ;

Stern, A ;

Schmidt, AM ;

Armstrong, DL ;

Arnold, B ;

Liliensiek, B ;

Nawroth, P ;

Hofman, F ;

Kindy, M ;

Stern, D ;

Zlokovic, B .

NATURE MEDICINE, 2003, 9 (07) :907-913

← 1 2 3 4 5 6 7 →