Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

被引：10
|
作者：
Goswami, Lakshmi [1 ,2 ]
Paul, Sayantan [1 ,2 ]
Kotammagari, Tharun K. [1 ,2 ]
Bhattacharya, Asish K. [1 ,2 ]
机构：
[1] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[2] Acad Sci & Innovat Res AcSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
来源：
NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 10期
关键词：
AZIDE-ALKYNE CYCLOADDITION; ANTIMALARIAL-DRUG; DERIVATIVES; ENDOPEROXIDES; NITRILES; ETHER; PHASE;
D O I：
10.1039/c8nj05737k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we describe the synthesis of artemisinin based glycoconjugates (9a-i) through employing a Cu(i)-catalysed reaction between -propargylated dihydroartemisinin (7a) and azido sugars (8a-i), with moderate to excellent yields. Our synthesized artemisinin based glycoconjugates (9a-i) could prove to be an interesting class of bioactive molecules, suitable for the study of their various biological activities.
引用
收藏
页码：4017 / 4021
页数：5
相关论文
共 50 条
  • [41] Click Chemistry Applied in the Synthesis of Symmetrical Triphenylene-Based Discotic Liquid-Crystalline Dimers
    Thevenet, Damien
    Neier, Reinhard
    SYNTHESIS-STUTTGART, 2011, (23): : 3801 - 3806
  • [42] Artemisinin-(Iso)quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria
    Capci, Aysun
    Lorion, Melanie M.
    Wang, Hui
    Simon, Nina
    Leidenberger, Maria
    Silva, Mariana C. Borges
    Moreira, Diogo R. M.
    Zhu, Yongping
    Meng, Yuqing
    Chen, Jia Yun
    Lee, Yew Mun
    Friedrich, Oliver
    Kappes, Barbara
    Wang, Jigang
    Ackermann, Lutz
    Tsogoeva, Svetlana B.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (37) : 13066 - 13079
  • [43] The synthesis of amino acid derived glycoconjugates and the investigation of their anti-inflammatory and analgesic properties
    Soni, Kiran
    Sah, Ajay K.
    RSC ADVANCES, 2014, 4 (12) : 6068 - 6073
  • [44] Functionalization of Polysulfones by Click Chemistry
    Toiserkani, Hojjat
    Yilmaz, Gorkem
    Yagci, Yusuf
    Torun, Lokman
    MACROMOLECULAR CHEMISTRY AND PHYSICS, 2010, 211 (22) : 2389 - 2395
  • [45] Click reactions in chitosan chemistry
    A. S. Kritchenkov
    Yu. A. Skorik
    Russian Chemical Bulletin, 2017, 66 : 769 - 781
  • [46] Click chemistry in sphingolipid research
    Izquierdo, Eduardo
    Delgado, Antonio
    CHEMISTRY AND PHYSICS OF LIPIDS, 2018, 215 : 71 - 83
  • [47] Click Chemistry in Materials Science
    Xi, Weixian
    Scott, Timothy F.
    Kloxin, Christopher J.
    Bowman, Christopher N.
    ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (18) : 2572 - 2590
  • [48] NEW METHOD FOR THE SYNTHESIS OF ETHER DERIVATIVES OF ARTEMISININ
    Bora, Pranjal P.
    Baruah, Nabajyoti
    Bez, Ghanashyam
    Barua, Nabin C.
    SYNTHETIC COMMUNICATIONS, 2012, 42 (08) : 1218 - 1225
  • [49] Unnatural Amino Acid Derivatives through Click Chemistry: Synthesis of Triazolylalanine Analogues
    Patil, Pravin C.
    Luzzio, Frederick A.
    SYNLETT, 2017, 28 (14) : 1729 - 1732
  • [50] CAN catalysis and click chemistry routes in the synthesis of carborane-containing ferrocenes
    Ol'shevskaya, Valentina A.
    Makarenkov, Anton V.
    Borisov, Yury A.
    Ananyev, Ivan V.
    Kononova, Elena G.
    Kalinin, Valery N.
    Ponomaryov, Andrey B.
    POLYHEDRON, 2018, 141 : 181 - 190
12345