Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images

被引：50

作者：

Asao, Yasufumi ^{[1
,2
]}

Hashizume, Yohei ^{[1
]}

Suita, Takahiro ^{[1
]}

Nagae, Ken-ichi ^{[1
]}

Fukutani, Kazuhiko ^{[1
]}

Sudo, Yoshiaki ^{[1
]}

Matsushita, Toshikazu ^{[1
]}

Kobayashi, Shuichi ^{[1
]}

Tokiwa, Mariko ^{[2
]}

Yamaga, Iku ^{[2
]}

Fakhrejahani, Elham ^{[2
]}

Torii, Masae ^{[2
]}

Kawashima, Masahiro ^{[2
]}

Takada, Masahiro ^{[2
]}

Kanao, Shotaro ^{[3
]}

Kataoka, Masako ^{[3
]}

Shiina, Tsuyoshi ^{[4
]}

Toi, Masakazu ^{[2
]}

机构：

[1] Canon Inc, Med Imaging Dev Ctr, Ohta Ku, 3-30-2 Shimomaruko, Tokyo 1468501, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Breast Surg, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2016年 / 21卷 / 11期

关键词：

photoacoustic imaging; optoacoustic; mammography; ultrasound; DIFFUSE OPTICAL TOMOGRAPHY; BREAST-CANCER; TISSUE; ANGIOGENESIS; SYSTEM; SPECTROSCOPY; CARCINOMA; PATTERNS; CONTRAST; HYPOXIA;

D O I：

10.1117/1.JBO.21.11.116009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research. (C) The Authors. Published by SPIE

引用

页数：12

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