Right Ventricular Adaptation and Maladaptation in Chronic Pulmonary Arterial Hypertension

被引：42

作者：

Rich, Stuart ^{[1
]}

机构：

[1] Univ Chicago, Dept Med, Cardiol Sect, Chicago, IL 60637 USA

来源：

CARDIOLOGY CLINICS | 2012年 / 30卷 / 02期

关键词：

Right ventricle; Pulmonary hypertension; Heart failure; Adaptation; Maladaptation; HEART-FAILURE; EPOPROSTENOL THERAPY; K+ CHANNELS; SURVIVAL; DYSFUNCTION; SILDENAFIL; PROSTACYCLIN; BLOCKERS; DISEASE;

D O I：

10.1016/j.ccl.2012.03.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The right ventricle (RV) is not well suited to chronic pressure overload and often fails to adequately compensate. Mechanisms that allow the RV to respond to acute pressure overload often become maladaptive and contribute to its failure, including the effects of pulmonary hypertension on RV myocardial perfusion, the influence of interventricular dependence on RV function, and metabolic shifts in the RV myocardium from fatty acid to glycolysis. Medications to treat pulmonary hypertension have focused on pulmonary vasodilatation. Their effects on RV function may determine their effectiveness. How new medications affect right ventricular performance must be addressed.

引用

页码：257 / +

页数：14

共 45 条

[41] Long-term intravenous epoprostenol infusion in primary pulmonary hypertension -: Prognostic factors and survival [J].

Sitbon, O ;

Humbert, M ;

Nunes, H ;

Parent, F ;

Garcia, G ;

Hervé, P ;

Rainisio, M ;

Simonneau, G .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (04) :780-788

[42] Progressive Right Ventricular Dysfunction in Patients With Pulmonary Arterial Hypertension Responding to Therapy [J].

van de Veerdonk, Marielle C. ;

Kind, Taco ;

Marcus, J. Tim ;

Mauritz, Gert-Jan ;

Heymans, Martijn W. ;

Bogaard, Harm-Jan ;

Boonstra, Anco ;

Marques, Koen M. J. ;

Westerhof, Nico ;

Vonk-Noordegraaf, Anton .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (24) :2511-2519

[43] THE PATHO-PHYSIOLOGY OF FAILURE IN ACUTE RIGHT VENTRICULAR HYPERTENSION - HEMODYNAMIC AND BIOCHEMICAL CORRELATIONS [J].

VLAHAKES, GJ ;

TURLEY, K ;

HOFFMAN, JIE .

CIRCULATION, 1981, 63 (01) :87-95

[44] Diastolic ventricular interaction: from physiology to clinical practice [J].

Williams, L ;

Frenneaux, M .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2006, 3 (07) :368-376

[45] Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension [J].

Yuan, JXJ ;

Aldinger, AM ;

Juhaszova, M ;

Wang, J ;

Conte, JV ;

Gaine, SP ;

Orens, JB ;

Rubin, LJ .

CIRCULATION, 1998, 98 (14) :1400-1406

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