Biochemical premotor biomarkers for Parkinson's disease

被引：29

作者：

Mollenhauer, Brit ^{[1
,2
]}

Zhang, Jing ^{[3
]}

机构：

[1] Paracelsus Elena Klin, D-34128 Kassel, Germany

[2] Univ Gottingen, Kassel, Germany

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 05期

关键词：

biomarkers; genomics; metabolomics; Parkinson's disease; premotor; proteomics; HUMAN CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; GENE-EXPRESSION; URIC-ACID; ALZHEIMER; PROTEIN; URATE; DJ-1; CSF; PROTEOMICS;

D O I：

10.1002/mds.24956

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric a-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide ddetails about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future. (C) 2012 Movement Disorder Society

引用

页码：644 / 650

页数：7

共 61 条

[51] Mortalin: A protein associated with progression of Parkinson disease? [J].

Shi, Min ;

Jin, Jinghua ;

Wang, Yan ;

Beyer, Richard P. ;

Kitsou, Efstathia ;

Albin, Roger L. ;

Gearing, Marla ;

Pan, Catherine ;

Zhang, Jing .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2008, 67 (02) :117-124

[52] Cerebrospinal Fluid Biomarkers for Parkinson Disease Diagnosis and Progression [J].

Shi, Min ;

Bradner, Joshua ;

Hancock, Aneeka M. ;

Chung, Kathryn A. ;

Quinn, Joseph F. ;

Peskind, Elaine R. ;

Galasko, Douglas ;

Jankovic, Joseph ;

Zabetian, Cyrus P. ;

Kim, Hojoong M. ;

Leverenz, James B. ;

Montine, Thomas J. ;

Ginghina, Carmen ;

Kang, Un Jung ;

Cain, Kevin C. ;

Wang, Yu ;

Aasly, Jan ;

Goldstein, David ;

Zhang, Jing .

ANNALS OF NEUROLOGY, 2011, 69 (03) :570-580

[53] alpha-synuclein in Lewy bodies [J].

Spillantini, MG ;

Schmidt, ML ;

Lee, VMY ;

Trojanowski, JQ ;

Jakes, R ;

Goedert, M .

NATURE, 1997, 388 (6645) :839-840

[54] Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease [J].

Tokuda, T. ;

Qureshi, M. M. ;

Ardah, M. T. ;

Varghese, S. ;

Shehab, S. A. S. ;

Kasai, T. ;

Ishigami, N. ;

Tamaoka, A. ;

Nakagawa, M. ;

El-Agnaf, O. M. A. .

NEUROLOGY, 2010, 75 (20) :1766-1772

[55] Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease [J].

Tokuda, Takahiko ;

Salem, Sultan A. ;

Allsop, David ;

Mizuno, Toshiki ;

Nakagawa, Masanori ;

Qureshi, Mohamed M. ;

Locascio, Joseph J. ;

Schlossmacher, Michael G. ;

El-Agnaf, Omar M. A. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 349 (01) :162-166

[56] Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease [J].

Valappil, Ruksana Azhu ;

Black, Jed E. ;

Broderick, Meredith J. ;

Carrillo, Oscar ;

Frenette, Eric ;

Sullivan, Shannon S. ;

Goldman, Samuel M. ;

Tanner, Caroline M. ;

Langston, James W. .

MOVEMENT DISORDERS, 2010, 25 (14) :2296-2303

[57] Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease [J].

Waragai, Masaaki ;

Wei, Jianshe ;

Fujita, Masayo ;

Nakai, Masaaki ;

Ho, Gilbert J. ;

Masliah, Eliezer ;

Akatsu, Hiroyasu ;

Yamada, Tatsuo ;

Hashimoto, Makoto .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (03) :967-972

[58] Plasma urate and risk of Parkinson's disease [J].

Weisskopf, M. G. ;

O'Reilly, E. ;

Chen, H. ;

Schwarzschild, M. A. ;

Ascherio, A. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (05) :561-567

[59] CEREBROSPINAL-FLUID FROM PATIENTS WITH PARKINSONS-DISEASE ALTERS THE SURVIVAL OF DOPAMINE NEURONS IN MESENCEPHALIC CULTURE [J].

YU, SJ ;

LO, ES ;

COCHRAN, EJ ;

LIN, DH ;

FASELIS, CJ ;

KLAWANS, HL ;

CARVEY, PM .

EXPERIMENTAL NEUROLOGY, 1994, 126 (01) :15-24

[60] CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases [J].

Zhang, Jing ;

Sokal, Izabela ;

Peskind, Elaine R. ;

Quinn, Joseph F. ;

Jankovic, Joseph ;

Kenney, Christopher ;

Chung, Kathryn A. ;

Millard, Steven P. ;

Nutt, John G. ;

Montine, Thomas J. .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 129 (04) :526-529

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