Biochemical premotor biomarkers for Parkinson's disease

被引：29

作者：

Mollenhauer, Brit ^{[1
,2
]}

Zhang, Jing ^{[3
]}

机构：

[1] Paracelsus Elena Klin, D-34128 Kassel, Germany

[2] Univ Gottingen, Kassel, Germany

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 05期

关键词：

biomarkers; genomics; metabolomics; Parkinson's disease; premotor; proteomics; HUMAN CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; GENE-EXPRESSION; URIC-ACID; ALZHEIMER; PROTEIN; URATE; DJ-1; CSF; PROTEOMICS;

D O I：

10.1002/mds.24956

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric a-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide ddetails about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future. (C) 2012 Movement Disorder Society

引用

页码：644 / 650

页数：7

共 61 条

[1]

Abdi F, 2006, J ALZHEIMERS DIS, V9, P293

[2] CSF α-synuclein does not differentiate between parkinsonian disorders [J].

Aerts, M. B. ;

Esselink, R. A. J. ;

Abdo, W. F. ;

Bloem, B. R. ;

Verbeek, M. M. .

NEUROBIOLOGY OF AGING, 2012, 33 (02) :430.e1-430.e3

[3] URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].

AMES, BN ;

CATHCART, R ;

SCHWIERS, E ;

HOCHSTEIN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862

[4] Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease [J].

Anderson, John P. ;

Walker, Donald E. ;

Goldstein, Jason M. ;

de laat, Rian ;

Banducci, Kelly ;

Caccavello, Russell J. ;

Barbour, Robin ;

Huang, Jiping ;

Kling, Kristin ;

Lee, Michael ;

Diep, Linnea ;

Keim, Pamela S. ;

Shen, Xiaofeng ;

Chataway, Tim ;

Schlossmacher, Michael G. ;

Seubert, Peter ;

Schenk, Dale ;

Sinha, Sukanto ;

Gai, Wei Ping ;

Chilcote, Tamie J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (40) :29739-29752

[5] Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins [J].

Anderson, L ;

Hunter, CL .

MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (04) :573-588

[6] Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice [J].

Andreasen, N ;

Minthon, L ;

Davidsson, P ;

Vanmechelen, E ;

Vanderstichele, H ;

Winblad, B ;

Blennow, K .

ARCHIVES OF NEUROLOGY, 2001, 58 (03) :373-379

[7] Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease [J].

Ascherio, Alberto ;

LeWitt, Peter A. ;

Xu, Kui ;

Eberly, Shirley ;

Watts, Arthur ;

Matson, Wayne R. ;

Marras, Connie ;

Kieburtz, Karl ;

Rudolph, Alice ;

Bogdanov, Mikhail B. ;

Schwid, Steven R. ;

Tennis, Marsha ;

Tanner, Caroline M. ;

Beal, M. Flint ;

Lang, Anthony E. ;

Oakes, David ;

Fahn, Stanley ;

Shoulson, Ira ;

Schwarzschild, Michael A. .

ARCHIVES OF NEUROLOGY, 2009, 66 (12) :1460-1468

[8] Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease [J].

Beyer, Katrin ;

Humbert, Jordi ;

Ferrer, Anna ;

Lao, Jose I. ;

Carrato, Cristina ;

Lopez, Dolores ;

Ferrer, Isidro ;

Ariza, Aurelio .

NEUROREPORT, 2006, 17 (12) :1327-1330

[9] Cerebrospinal fluid amyloid β peptide patterns in Alzheimer's disease patients and nondemented controls depend on sample pretreatment:: Indication of carrier-mediated epitope masking of amyloid β peptides [J].

Bibl, M ;

Esselmann, H ;

Otto, M ;

Lewczuk, P ;

Cepek, L ;

Rüther, E ;

Kornhuber, J ;

Wiltfang, J .

ELECTROPHORESIS, 2004, 25 (17) :2912-2918

[10] Metabolomic profiling to develop blood biomarkers for Parkinson's disease [J].

Bogdanov, Mikhail ;

Matson, Wayne R. ;

Wang, Lei ;

Matson, Theodore ;

Saunders-Pullman, Rachel ;

Bressman, Susan S. ;

Beal, M. Flint .

BRAIN, 2008, 131 :389-396

← 1 2 3 4 5 6 7 →