Biocatalytic production of tetrahydroisoquinolines

被引：77

作者：

Ruff, Bettina M. ^{[2
,3
]}

Braese, S. ^{[3
]}

O'Connor, Sarah E. ^{[1
,4
]}

机构：

[1] John Innes Ctr, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

[3] Karlsruhe Inst Technol, Inst Organ Chem, D-76137 Karlsruhe, Germany

[4] Univ E Anglia, Norwich NR4 7TJ, Norfolk, England

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 09期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Biocatalysis; Pictet-Spengler reaction; Norcoclaurine synthase; Tetrahydroisoquinoline alkaloids; NORCOCLAURINE SYNTHASE; ANALOGS; ENZYME;

D O I：

10.1016/j.tetlet.2011.12.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1071 / 1074

页数：4

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