Serum Trace Metal Levels in Alzheimer's Disease and Normal Control Groups

被引：38
作者：
Park, Jun-Hyun [1 ]
Lee, Dong-Woo [1 ]
Park, Kyung Su [2 ]
Joung, HyoJee [3 ,4 ]
机构：
[1] Inje Univ, Dept Psychiat, Sanggye Paik Hosp, Coll Med, Seoul, South Korea
[2] Korea Inst Sci & Technol, Adv Anal Ctr, Seoul, South Korea
[3] Seoul Natl Univ, Dept Publ Hlth, Grad Sch Publ Hlth, Seoul, South Korea
[4] Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea
来源：
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2014年 / 29卷 / 01期
关键词：
MILD COGNITIVE IMPAIRMENT; LEAD-EXPOSURE; CUMULATIVE LEAD; CEREBROSPINAL-FLUID; ARSENIC EXPOSURE; CADMIUM; MERCURY; BRAIN; WORKERS; RATS;
D O I：
10.1177/1533317513506778
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective: To determine whether serum trace metals are related to abnormal cognition in Alzheimer's disease (AD). Methods: We studied serum lead (Pb), cadmium (Cd), mercury (Hg), and arsenic(As) in 89 patients with AD and in 118 cognitively normal individuals. We analyzed the results of the blood tests and the food intake. Results: Serum Pb levels correlated with word list recall (P = .039) and word list recognition (P = .037). Without age adjustment, serum Cd levels (P = .044) were significantly higher in the AD group. After stratified age adjustment, the levels of selected trace metals did not differ significantly between AD 1 and normal individuals. Food intakes regarding selected trace metals were not significantly different between the 2 groups. Conclusions: In this study, serum Pb, Cd, Hg, and As levels were not directly related to abnormal cognition in AD. Serum Pb levels were significantly negatively correlated with verbal memory scores.
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页码：76 / 83
页数：8
相关论文
共 64 条
[1]  
Adlard PA, 2006, J ALZHEIMERS DIS, V10, P145
[2]   Recent findings on the phytoremediation of soils contaminated with environmentally toxic heavy metals and metalloids such as zinc, cadmium, lead, and arsenic [J].
Alkorta I. ;
Hernández-Allica J. ;
Becerril J.M. ;
Amezaga I. ;
Albizu I. ;
Garbisu C. .
Reviews in Environmental Science and Biotechnology, 2004, 3 (1) :71-90
[3]   Low-level cadmium exposure of lactating rats causes alterations in brain serotonin levels in the offspring [J].
Andersson, H ;
PeterssonGrawe, K ;
Lindqvist, E ;
Luthman, J ;
Oskarsson, A ;
Olson, L .
NEUROTOXICOLOGY AND TERATOLOGY, 1997, 19 (02) :105-115
[4]  
[Anonymous], SAS PROC GUID VERS 8
[5]  
Atwood CS, 1999, MET IONS BIOL SYST, V36, P309
[6]  
BASUN H, 1991, J NEURAL TRANSM-PARK, V3, P231
[7]  
BASUN H, 1994, BIOMETALS, V7, P130
[8]   Impact of cognitive reserve on the relationship of lead exposure and neurobehavioral performance [J].
Bleecker, M. L. ;
Ford, D. P. ;
Celio, M. A. ;
Vaughan, C. G. ;
Lindgren, K. N. .
NEUROLOGY, 2007, 69 (05) :470-476
[9]  
Bocca Beatrice, 2005, Ann Ist Super Sanita, V41, P197
[10]  
Bomboi Giuseppe, 2005, Ann Ist Super Sanita, V41, P205
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