Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a] quinoxaline derivatives through copper-catalyzed intramolecular N-arylation

被引：7
|
作者：
Zhao, Fei [1 ]
Zhang, Lei [1 ]
Liu, Hailong [1 ]
Zhou, Shengbin [1 ]
Liu, Hong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 9卷
基金：
中国国家自然科学基金;
关键词：
copper; 5,6-dihydroindolo[1,2-a]quinoxaline; intramolecular N-arylation; microwave irradiation; INDOLE ALKALOIDS; HETEROCYCLES; CHEMISTRY; EFFICIENT; CASCADE; AMINES; MILD; CUI;
D O I：
10.3762/bjoc.9.285
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[ 1,2-a] quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83-97%) in short reaction times (45-60 min).
引用
收藏
页码：2463 / 2469
页数：7
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