Liposomal formulation of amphotericin B for the treatment of mucosal leishmaniasis in HIV-negative patients

被引：28
|
作者：
Rocio, Carolina [1 ]
Amato, Valdir Sabbaga [1 ]
Camargo, Raphael A. [1 ]
Tuon, Felipe F. [2 ]
Nicodemo, Antonio Carlos [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, Sao Paulo, Brazil
[2] Univ Fed Parana, Clin Univ Hosp, Div Infect Dis, BR-80060000 Curitiba, PR, Brazil
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2014年 / 108卷 / 03期
关键词：
Amphotericin B; Leishmania treatment; Leishmaniasis;
D O I：
10.1093/trstmh/tru011
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: Studies assessing the efficacy of liposomal amphotericin B (LAB) in the treatment of patients with mucosal leishmaniasis (ML) are very scarce in the literature and an optimal dose regimen has not yet been defined. Methods: We performed a retrospective and descriptive analysis from records of 16 patients with ML treated with LAB. The mean daily dose of LAB was 2.5 mg/kg/day. Results: Healing of the lesion was observed in 14 (88%) of the 16 patients. The mean cumulative doses, excluding the two treatment failures, were 2265 mg and 33 mg/kg. Conclusion: Liposomal amphotericin B in the cumulative dose of 30 to 35 mg/kg was able to achieve 100% effectiveness.
引用
收藏
页码：176 / 178
页数：3
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