Mucor circinelloides as a Cause of Invasive Maxillofacial Zygomycosis: an Emerging Dimorphic Pathogen with Reduced Susceptibility to Posaconazole

被引：28

作者：

Khan, Zia U. ^{[1
]}

Ahmad, Suhail ^{[1
]}

Brazda, Arnost ^{[2
]}

Chandy, Rachel ^{[1
]}

机构：

[1] Kuwait Univ, Fac Med, Dept Microbiol, Safat 13110, Kuwait

[2] Farwanya Hosp, Minist Hlth, Dept Maxillofacial Surg, Farwanya, Kuwait

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 04期

关键词：

IN-VITRO SUSCEPTIBILITIES; BREAKTHROUGH ZYGOMYCOSIS; SALVAGE THERAPY; AMPHOTERICIN-B; VORICONAZOLE; IDENTIFICATION; MUCORMYCOSIS; CULTURE; DNA; GALACTOMANNAN;

D O I：

10.1128/JCM.02030-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A case of maxillofacial zygomycosis caused by Mucor circinelloides, identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.

引用

页码：1244 / 1248

页数：5

共 41 条

[31] Molecular identification of Zygomycetes from culture and experimentally infected tissues [J].

Schwarz, P ;

Bretagne, S ;

Gantier, JC ;

Garcia-Hermoso, D ;

Lortholary, O ;

Dromer, F ;

Dannaoui, E .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (02) :340-349

[32]

Shindo Motohiro, 2007, Rinsho Ketsueki, V48, P412

[33] Novel perspectives on mucormycosis: Pathophysiology, presentation, and management [J].

Spellberg, B ;

Edwards, J ;

Ibrahim, A .

CLINICAL MICROBIOLOGY REVIEWS, 2005, 18 (03) :556-+

[34] Identification of medically relevant Trichosporon species based on sequences of internal transcribed spacer regions and construction of a database for Trichosporon identification [J].

Sugita, T ;

Nishikawa, A ;

Ikeda, R ;

Shinoda, T .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (06) :1985-1993

[35] In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes [J].

Sun, QN ;

Fothergill, AW ;

McCarthy, DI ;

Rinaldi, MG ;

Graybill, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1581-1582

[36] Diagnosis of invasive septate mold infections - A correlation of microbiological culture and histologic or cytologic examination [J].

Tarrand, JJ ;

Lichterfeld, M ;

Warraich, I ;

Luna, M ;

Han, XY ;

May, GS ;

Kontoyiannis, DP .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2003, 119 (06) :854-858

[37] In vitro activities of amphotericin B, caspofungin, itraconazole, posaconazole, and voriconazole against 45 clinical isolates of zygomycetes:: Comparison of CLSI M38-A, sensititre YeastOne, and the Etest [J].

Torres-Narbona, Marta ;

Guinea, Jesus ;

Martinez-Alarcon, Jose ;

Pelaez, Teresa ;

Bouza, Emilio .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (03) :1126-1129

[38] Breakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapy [J].

Trifilio, S. M. ;

Bennett, C. L. ;

Yarnold, P. R. ;

McKoy, J. M. ;

Parada, J. ;

Mehta, J. ;

Chamilos, G. ;

Palella, F. ;

Kennedy, L. ;

Mullane, K. ;

Tallman, M. S. ;

Evens, A. ;

Scheetz, M. H. ;

Blum, W. ;

Kontoyiannis, D. P. .

BONE MARROW TRANSPLANTATION, 2007, 39 (07) :425-429

[39] Posaconazole is effective as salvage therapy in zygomycosis: A retrospective summary of 91 cases [J].

van Burik, JAH ;

Hare, RS ;

Solomon, HF ;

Corrado, ML ;

Kontoyiannis, DP .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (07) :E61-E65

[40] Phylogeny and PCR identification of clinically important zygomycetes based on nuclear ribosomal-DNA sequence data [J].

Voigt, K ;

Cigelnik, E ;

O'Donnell, K .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (12) :3957-3964

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