Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells

被引：171

作者：

Prashar, A. ^{[1
]}

Locke, I. C. ^{[1
]}

Evans, C. S. ^{[1
]}

机构：

[1] Univ Westminster, Sch Biosci, London W1W 6UW, England

来源：

CELL PROLIFERATION | 2006年 / 39卷 / 04期

关键词：

D O I：

10.1111/j.1365-2184.2006.00384.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The essential oil extracted from clove (Syzygium aromaticum) is used as a topical application to relieve pain and promote healing in herbal medicine and also finds use in the fragrance and flavouring industries. Clove oil has two major components, eugenol and beta-caryophyllene, which constitute 78% and 13% of the oil, respectively. Clove oil and these components are generally recognized as 'safe', but the in-vitro study here demonstrates cytotoxic properties of both the oil and eugenol, towards human fibroblasts and endothelial cells. Clove oil was found to be highly cytotoxic at concentrations as low as 0.03% (v/v) with up to 73% of this effect attributable to eugenol. beta-caryophyllene did not exhibit any cytotoxic activity, indicating that other cytotoxic components may also exist within the parent oil.

引用

页码：241 / 248

页数：8

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