Pruritus: Is there a grain of salty truth?

被引：7
作者：
Penny, Jarrin D. [1 ,2 ]
Salerno, Fabio R. [1 ,2 ]
Akbari, Alireza [1 ]
McIntyre, Christopher W. [1 ,2 ,3 ,4 ]
机构：
[1] Western Univ, Lilibeth Caberto Kidney Clin Res Unit, London, ON, Canada
[2] Western Univ, Dept Med Biophys, London, ON, Canada
[3] London Hlth Sci Ctr, Div Nephrol, London, ON, Canada
[4] Lawson Hlth Res Inst, London, ON, Canada
来源：
HEMODIALYSIS INTERNATIONAL | 2021年 / 25卷 / 01期
基金：
加拿大健康研究院;
关键词：
Sodium; hemodialysis; pruritus; symptoms; MRI; expanded dialysis; UREMIC PRURITUS; NA+ STORAGE; HEMODIALYSIS;
D O I：
10.1111/hdi.12885
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Hemodialysis patients characteristically suffer from a range of unpleasant symptoms. Uremic pruritus effects close to half of the chronic kidney disease population, reducing quality of life and associated with increased mortality. Its pathophysiology though is poorly understood; currently deployed therapeutic approaches are ineffective. Excessive levels of skin and soft tissue sodium accumulate in dialysis patients, producing a range of biological consequences, including inflammation. We report an index case of a hemodialysis patient with debilitating pruritus and extreme levels of tissue sodium, measured with Sodium-23 magnetic resonance imaging. Both the tissue sodium loading and pruritus responded fully to initiation of expanded hemodialysis therapy with a recently introduced medium cutoff dialysis membrane-based dialyzer.
引用
收藏
页码：E10 / E14
页数：5
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