Separation of enantiomers of drugs by capillary electrophoresis .4. Hydroxypropyl-gamma-cyclodextrin as chiral solvating agent

被引：41
|
作者：
Koppenhoefer, B [1 ]
Epperlein, U [1 ]
Zhu, XF [1 ]
Lin, BC [1 ]
机构：
[1] INST CHEM PHYS,DALIAN,PEOPLES R CHINA
来源：
ELECTROPHORESIS | 1997年 / 18卷 / 06期
关键词：
capillary electrophoresis; enantiomer separation; chiral drugs; hydroxypropyl-gamma-cyclodextrin;
D O I：
10.1002/elps.1150180612
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.
引用
收藏
页码：924 / 930
页数：7
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