Separation of enantiomers of drugs by capillary electrophoresis .4. Hydroxypropyl-gamma-cyclodextrin as chiral solvating agent

被引：41

作者：

Koppenhoefer, B ^{[1
]}

Epperlein, U ^{[1
]}

Zhu, XF ^{[1
]}

Lin, BC ^{[1
]}

机构：

[1] INST CHEM PHYS,DALIAN,PEOPLES R CHINA

来源：

ELECTROPHORESIS | 1997年 / 18卷 / 06期

关键词：

capillary electrophoresis; enantiomer separation; chiral drugs; hydroxypropyl-gamma-cyclodextrin;

D O I：

10.1002/elps.1150180612

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.

引用

页码：924 / 930

页数：7

共 22 条

[1]

[Anonymous], 1990, CHIRALITY DRUG DESIG

[2] CHIRAL SEPARATIONS OF BASIC AND ACIDIC COMPOUNDS IN MODIFIED CAPILLARIES USING CYCLODEXTRIN-MODIFIED CAPILLARY ZONE ELECTROPHORESIS [J].