SIRT6: Novel Mechanisms and Links to Aging and Disease

被引：191

作者：

Tasselli, Luisa ^{[1
,2
]}

Zheng, Wei ^{[1
,2
]}

Chua, Katrin F. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[2] Vet Affairs Palo Alto Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Palo Alto, CA 94304 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 03期

关键词：

HISTONE DEACETYLASE SIRT6; CANCER-CELLS; STEM-CELLS; GENOMIC INSTABILITY; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; TRANSCRIPTION FACTOR; PANCREATIC-CANCER; TUMOR-SUPPRESSOR; LIPID-METABOLISM;

D O I：

10.1016/j.tem.2016.10.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SIRT6, a member of the Sirtuin family of NAD(+)-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and cancer, and can promote longevity in mice. Research from the past few years revealed that SIRT6 is a complex enzyme with multiple substrates and catalytic activities, and uncovered novel SIRT6 functions in the maintenance of organismal health span. Here, we review these new discoveries and models of SIRT6 biology in four areas: heterochromatin stabilization and silencing; stem cell biology; cancer initiation and progression; and regulation of metabolic homeostasis. We discuss the possible implications of these findings for therapeutic interventions in aging and aging-related disease processes.

引用

页码：168 / 185

页数：18