共 283 条
Enzymes of triacylglycerol synthesis and their regulation
被引:744
作者:

Coleman, RA
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机构:
Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA

Lee, DP
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机构: Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA
机构:
[1] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA
关键词:
D O I:
10.1016/S0163-7827(03)00051-1
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions and the factors that regulate triacylglycerol biosynthesis. In the last few decades, in part due to advances in technology and the wide availability of nucleotide and amino acid sequences, we have made enormous strides in our understanding of these enzymes at the molecular level. In many cases, sequence information obtained from lipid biosynthetic enzymes of prokaryotes and yeast has provided the means to search the genomic and expressed sequence tag databases for mammalian homologs and most of the genes have now been identified. Surprisingly, multiple isoforms appear to catalyze the same chemical reactions, suggesting that each isoform may play a distinct functional role in the pathway of triacylglycerol and phospholipid biosynthesis. This review focuses on the de novo biosynthesis of triacylglycerol in eukaryotic cells, the isoenzymes that are involved, their subcellular locations, how they are regulated, and their putative individual roles in glycerolipid biosynthesis. (C) 2003 Elsevier Ltd. All rights reserved.
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页码:134 / 176
页数:43
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共 283 条
[1]
Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases
[J].
Abo-Hashema, KAH
;
Cake, MH
;
Power, GW
;
Clarke, D
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (50)
:35577-35582

Abo-Hashema, KAH
论文数: 0 引用数: 0
h-index: 0
机构: Murdoch Univ, Sch Biol Sci & Biotechnol, Div Sci & Engn, Murdoch, WA 6150, Australia

Cake, MH
论文数: 0 引用数: 0
h-index: 0
机构:
Murdoch Univ, Sch Biol Sci & Biotechnol, Div Sci & Engn, Murdoch, WA 6150, Australia Murdoch Univ, Sch Biol Sci & Biotechnol, Div Sci & Engn, Murdoch, WA 6150, Australia

Power, GW
论文数: 0 引用数: 0
h-index: 0
机构: Murdoch Univ, Sch Biol Sci & Biotechnol, Div Sci & Engn, Murdoch, WA 6150, Australia

Clarke, D
论文数: 0 引用数: 0
h-index: 0
机构: Murdoch Univ, Sch Biol Sci & Biotechnol, Div Sci & Engn, Murdoch, WA 6150, Australia
[2]
FAT ACCUMULATION IN THE RAT-HEART DURING FASTING
[J].
ADAMS, MG
;
BARER, R
;
JOSEPH, S
;
OMINIABOHS, F
.
JOURNAL OF PATHOLOGY,
1981, 135 (02)
:111-126

ADAMS, MG
论文数: 0 引用数: 0
h-index: 0

BARER, R
论文数: 0 引用数: 0
h-index: 0

JOSEPH, S
论文数: 0 引用数: 0
h-index: 0

OMINIABOHS, F
论文数: 0 引用数: 0
h-index: 0
[3]
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
[J].
Agarwal, AK
;
Arioglu, E
;
de Almeida, S
;
Akkoc, N
;
Taylor, SI
;
Bowcock, AM
;
Barnes, RI
;
Garg, A
.
NATURE GENETICS,
2002, 31 (01)
:21-23

Agarwal, AK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Arioglu, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

de Almeida, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Akkoc, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Taylor, SI
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Bowcock, AM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Barnes, RI
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA

Garg, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Internal Med, Div Nutr & Metab Dis, Dallas, TX 75390 USA
[4]
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
[J].
Aguado, B
;
Campbell, RD
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1998, 273 (07)
:4096-4105

Aguado, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Biochem, MRC, Immunochem Unit, Oxford OX1 3QU, England Univ Oxford, Dept Biochem, MRC, Immunochem Unit, Oxford OX1 3QU, England

Campbell, RD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Biochem, MRC, Immunochem Unit, Oxford OX1 3QU, England Univ Oxford, Dept Biochem, MRC, Immunochem Unit, Oxford OX1 3QU, England
[5]
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432
[J].
Alvarez, HM
;
Souto, MF
;
Viale, A
;
Pucci, OH
.
FEMS MICROBIOLOGY LETTERS,
2001, 200 (02)
:195-200

Alvarez, HM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nacl Patagonia San Juan Bosco, Fac Ciencias Nat, CEIMA, RA-9000 Comodoro Rivadavia, Chubut, Argentina

Souto, MF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nacl Patagonia San Juan Bosco, Fac Ciencias Nat, CEIMA, RA-9000 Comodoro Rivadavia, Chubut, Argentina

Viale, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nacl Patagonia San Juan Bosco, Fac Ciencias Nat, CEIMA, RA-9000 Comodoro Rivadavia, Chubut, Argentina

Pucci, OH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nacl Patagonia San Juan Bosco, Fac Ciencias Nat, CEIMA, RA-9000 Comodoro Rivadavia, Chubut, Argentina
[6]
Biocompatible alginate from freshly collected Laminaria pallida for implantation
[J].
Jork, A
;
Thürmer, F
;
Cramer, H
;
Zimmermann, G
;
Gessner, P
;
Hämel, K
;
Hofmann, G
;
Kuttler, B
;
Hahn, HJ
;
Josimovic-Alasevic, O
;
Fritsch, KG
;
Zimmermann, U
.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,
2000, 53 (02)
:224-229

Jork, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Thürmer, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Cramer, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Zimmermann, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Gessner, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Hämel, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Hofmann, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Kuttler, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Hahn, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Josimovic-Alasevic, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Fritsch, KG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany

Zimmermann, U
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany Univ Wurzburg, Biozentrum, Dept Biotechnol, Wurzburg, Germany
[7]
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
[J].
Amemiya-Kudo, M
;
Shimano, H
;
Yoshikawa, T
;
Yahagi, N
;
Hasty, AH
;
Okazaki, H
;
Tamura, Y
;
Shionoiri, F
;
Iizuka, Y
;
Ohashi, K
;
Osuga, J
;
Harada, K
;
Gotoda, T
;
Sato, R
;
Kimura, S
;
Ishibashi, S
;
Yamada, N
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2000, 275 (40)
:31078-31085

Amemiya-Kudo, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Shimano, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Yoshikawa, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Yahagi, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Hasty, AH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Okazaki, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Tamura, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Shionoiri, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Iizuka, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Ohashi, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Osuga, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Harada, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Gotoda, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Sato, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

论文数: 引用数:
h-index:
机构:

Ishibashi, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan

Yamada, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan
[8]
The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade
[J].
Andresen, BT
;
Rizzo, MA
;
Shome, K
;
Romero, G
.
FEBS LETTERS,
2002, 531 (01)
:65-68

Andresen, BT
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA

Rizzo, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA

Shome, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA

Romero, G
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA
[9]
Serum lysophosphatidic acid is produced through diverse phospholipase pathways
[J].
Aoki, J
;
Taira, A
;
Takanezawa, Y
;
Kishi, Y
;
Hama, K
;
Kishimoto, T
;
Mizuno, K
;
Saku, K
;
Taguchi, R
;
Arai, H
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2002, 277 (50)
:48737-48744

Aoki, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Taira, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Takanezawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Kishi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Hama, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Kishimoto, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Mizuno, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Saku, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Taguchi, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

Arai, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[10]
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
[J].
Aoyama, T
;
Peters, JM
;
Iritani, N
;
Nakajima, T
;
Furihata, K
;
Hashimoto, T
;
Gonzalez, FJ
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1998, 273 (10)
:5678-5684

Aoyama, T
论文数: 0 引用数: 0
h-index: 0
机构:
Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Peters, JM
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Iritani, N
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Nakajima, T
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Furihata, K
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Hashimoto, T
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan

Gonzalez, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Shinshu Univ, Sch Med, Dept Biochem, Asahi Ku, Nagano 390, Japan