Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells

被引：34

作者：

Nabatanzi, Rose ^{[1
]}

Cose, Stephen ^{[2
,3
]}

Joloba, Moses ^{[1
]}

Jones, Sarah Rowland ^{[4
]}

Nakanjako, Damalie ^{[5
,6
]}

机构：

[1] Makerere Univ, Coll Hlth Sci, Dept Immunol & Mol Biol, POB 7072, Kampala, Uganda

[2] MRC UVRI Uganda Res Unit AIDS, London, England

[3] London Sch Hyg & Trop Med, London, England

[4] Univ Oxford, Nuffield Dept Med, Oxford, England

[5] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda

[6] Makerere Univ, Coll Hlth Sci, Infect Dis Inst, Kampala, Uganda

来源：

AIDS RESEARCH AND THERAPY | 2018年 / 15卷

基金：

英国惠康基金;

关键词：

HIV; Innate immunity; Monocytes; Natural killer cells; Innate lymphoid cells; Antiretroviral therapy; RECONSTITUTION INFLAMMATORY SYNDROME; NK-CELLS; IMMUNE ACTIVATION; ANTIRETROVIRAL THERAPY; MICROBIAL TRANSLOCATION; RESPONSES; CD4; DIFFERENTIATION; RESTORATION; NORMALIZATION;

D O I：

10.1186/s12981-018-0194-y

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretro-viral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery.

引用

页数：8

共 92 条

[1] Innate lymphoid cells: models of plasticity for immune homeostasis and rapid responsiveness in protection [J].

Almeida, F. F. ;

Belz, G. T. .

MUCOSAL IMMUNOLOGY, 2016, 9 (05) :1103-1112

[2] NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection [J].

Alter, G. ;

Altfeld, M. .

JOURNAL OF INTERNAL MEDICINE, 2009, 265 (01) :29-42

[3] Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection [J].

Alter, G ;

Teigen, N ;

T Davis, B ;

Addo, MM ;

Suscovich, TJ ;

Waring, MT ;

Streeck, H ;

Johnston, MN ;

Staller, KD ;

Zaman, MT ;

Yu, XG ;

Lichterfeld, M ;

Basgoz, N ;

Rosenberg, ES ;

Altfeld, M .

BLOOD, 2005, 106 (10) :3366-3369

[4] DCs and NK cells: critical effectors in the immune response to HIV-1 [J].

Altfeld, Marcus ;

Fadda, Lena ;

Frleta, Davor ;

Bhardwaj, Nina .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (03) :176-186

[5] Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients [J].

Amirayan-Chevillard, N ;

Tissot-Dupont, H ;

Capo, C ;

Brunet, C ;

Dignat-George, F ;

Obadia, Y ;

Gallais, H ;

Mege, JL .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 120 (01) :107-112

[6] Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients [J].

Ancuta, Petronela ;

Kamat, Anupa ;

Kunstman, Kevin J. ;

Kim, Eun-Young ;

Autissier, Patrick ;

Wurcel, Alysse ;

Zaman, Tauheed ;

Stone, David ;

Mefford, Megan ;

Morgello, Susan ;

Singer, Elyse J. ;

Wolinsky, Steven M. ;

Gabuzda, Dana .

PLOS ONE, 2008, 3 (06)

[7] Mycobacterial Antigen Driven Activation of CD14++ CD16- Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome [J].

Andrade, Bruno B. ;

Singh, Amrit ;

Narendran, Gopalan ;

Schechter, Melissa E. ;

Nayak, Kaustuv ;

Subramanian, Sudha ;

Anbalagan, Selvaraj ;

Jensen, Stig M. R. ;

Porter, Brian O. ;

Antonelli, Lis R. ;

Wilkinson, Katalin A. ;

Wilkinson, Robert J. ;

Meintjes, Graeme ;

van der Plas, Helen ;

Follmann, Dean ;

Barber, Daniel L. ;

Swaminathan, Soumya ;

Sher, Alan ;

Sereti, Irini .

PLOS PATHOGENS, 2014, 10 (10)

[8] Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART [J].

Anzinger, Joshua J. ;

Butterfield, Tiffany R. ;

Angelovich, Thomas A. ;

Crowe, Suzanne M. ;

Palmer, Clovis S. .

JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014

[9] Immune activation and inflammation in HIV-I infection: causes and consequences [J].

Appay, V. ;

Sauce, D. .

JOURNAL OF PATHOLOGY, 2008, 214 (02) :231-241

[10]

Appay V., 2016, VIRULENCE, V16, P1

← 1 2 3 4 5 6 7 8 9 10 →